Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1803907..1804704 Replicon chromosome
Accession NZ_CP056737
Organism Enterobacter roggenkampii strain RHBSTW-00309

Toxin (Protein)


Gene name KacT Uniprot ID A0A155TD66
Locus tag HV150_RS08715 Protein ID WP_032651255.1
Coordinates 1804183..1804704 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag HV150_RS08710 Protein ID WP_008499829.1
Coordinates 1803907..1804176 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV150_RS08680 1799532..1799975 - 444 WP_008499834.1 helix-turn-helix transcriptional regulator -
HV150_RS08685 1800128..1801369 + 1242 WP_008499833.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
HV150_RS08690 1801403..1801630 - 228 WP_008499832.1 YccJ family protein -
HV150_RS08695 1801651..1802247 - 597 WP_008499831.1 NAD(P)H:quinone oxidoreductase -
HV150_RS08700 1802639..1802809 + 171 WP_013097201.1 general stress protein -
HV150_RS08705 1802928..1803845 + 918 WP_025912980.1 DMT family transporter -
HV150_RS08710 1803907..1804176 + 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
HV150_RS08715 1804183..1804704 + 522 WP_032651255.1 GNAT family N-acetyltransferase Toxin
HV150_RS08720 1804778..1806100 - 1323 WP_104948907.1 pyrimidine utilization transport protein G -
HV150_RS08725 1806122..1806616 - 495 WP_023327078.1 pyrimidine utilization flavin reductase protein F -
HV150_RS08730 1806626..1807216 - 591 WP_106106141.1 malonic semialdehyde reductase -
HV150_RS08735 1807226..1808026 - 801 WP_106106140.1 pyrimidine utilization protein D -
HV150_RS08740 1808034..1808420 - 387 WP_008499822.1 pyrimidine utilization protein C -
HV150_RS08745 1808432..1809121 - 690 WP_047745127.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19714.46 Da        Isoelectric Point: 7.0497

>T164062 WP_032651255.1 NZ_CP056737:1804183-1804704 [Enterobacter roggenkampii]
VDNLTIEMFSEGKDYDFRDFDCGEPSLNVFLTEHLVRQHNGRILRGYLLKDRDGPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAIHKDLQGLEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNDQAKQFYLKQGFIPLTDENSHSLF
FPTKSIERLFEQA

Download         Length: 522 bp

>T164062 NZ_CP072790:c702192-701779 [Mycobacterium tuberculosis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT164062 WP_008499829.1 NZ_CP056737:1803907-1804176 [Enterobacter roggenkampii]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp

>AT164062 NZ_CP072790:c702425-702189 [Mycobacterium tuberculosis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155TD66

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References