Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1120151..1120771 Replicon chromosome
Accession NZ_CP056737
Organism Enterobacter roggenkampii strain RHBSTW-00309

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag HV150_RS05270 Protein ID WP_008499287.1
Coordinates 1120151..1120369 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag HV150_RS05275 Protein ID WP_008499288.1
Coordinates 1120397..1120771 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV150_RS05240 1116164..1116424 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
HV150_RS05245 1116427..1116567 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV150_RS05250 1116564..1117274 - 711 WP_025912637.1 GNAT family N-acetyltransferase -
HV150_RS05255 1117376..1118836 + 1461 WP_106106316.1 PLP-dependent aminotransferase family protein -
HV150_RS05260 1118808..1119275 - 468 WP_008499285.1 membrane protein -
HV150_RS05265 1119393..1119944 - 552 WP_045416680.1 maltose O-acetyltransferase -
HV150_RS05270 1120151..1120369 - 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
HV150_RS05275 1120397..1120771 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
HV150_RS05280 1121282..1124428 - 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit -
HV150_RS05285 1124451..1125644 - 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T164060 WP_008499287.1 NZ_CP056737:c1120369-1120151 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T164060 NZ_CP072790:682547-682954 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT164060 WP_008499288.1 NZ_CP056737:c1120771-1120397 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT164060 NZ_CP072790:682335-682550 [Mycobacterium tuberculosis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References