Detailed information of TA system TA164059

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 970424..971130
• Replicon: chromosome
• Accession: NZ_CP056737
• Organism: Enterobacter roggenkampii strain RHBSTW-00309

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A7D6YAQ1
• Locus tag: HV150_RS04600
• Protein ID: WP_071886833.1
• Coordinates: 970762..971130 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A7D6YLI3
• Locus tag: HV150_RS04595
• Protein ID: WP_045341350.1
• Coordinates: 970424..970741 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV150_RS04550	965873..966694	+	822	WP_045341364.1	DUF945 domain-containing protein	-
HV150_RS04555	966911..967612	+	702	WP_059291345.1	WYL domain-containing protein	-
HV150_RS04560	967653..967889	+	237	WP_001144029.1	hypothetical protein	-
HV150_RS04565	967889..968329	+	441	WP_059291346.1	hypothetical protein	-
HV150_RS04570	968353..968820	+	468	WP_158127750.1	hypothetical protein	-
HV150_RS04575	968897..969136	+	240	Protein_885	DUF905 domain-containing protein	-
HV150_RS04580	969236..969685	+	450	WP_045341356.1	antirestriction protein	-
HV150_RS04585	969694..970176	+	483	WP_045341354.1	DNA repair protein RadC	-
HV150_RS04590	970185..970406	+	222	WP_045341352.1	DUF987 domain-containing protein	-
HV150_RS04595	970424..970741	+	318	WP_045341350.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV150_RS04600	970762..971130	+	369	WP_071886833.1	TA system toxin CbtA family protein	Toxin
HV150_RS04605	971816..974125	+	2310	WP_045416779.1	TerB N-terminal domain-containing protein	-
HV150_RS04610	974129..975445	+	1317	WP_045416777.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	957992..992006	34014

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13738.90 Da
• Isoelectric Point: 8.1347

>T164059 WP_071886833.1 NZ_CP056737:970762-971130 [Enterobacter roggenkampii]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDQTVIQEHIDAGITLANAVNFLVEKYELVRIDRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSRQ

Nucleotide

• Length: 369 bp

>T164059 NZ_CP072790:c645266-644853 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11783.42 Da
• Isoelectric Point: 6.6236

>AT164059 WP_045341350.1 NZ_CP056737:970424-970741 [Enterobacter roggenkampii]
MNNTTWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISLMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYLYIVVYPTQS

Nucleotide

• Length: 318 bp

>AT164059 NZ_CP072790:c645529-645263 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Structures

Toxin

• AlphaFold DB: A0A7D6YAQ1

Antitoxin

• AlphaFold DB: A0A7D6YLI3