Detailed information of TA system TA164057

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 140489..141096
• Replicon: chromosome
• Accession: NZ_CP056737
• Organism: Enterobacter roggenkampii strain RHBSTW-00309

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HV150_RS00715
• Protein ID: WP_106105233.1
• Coordinates: 140489..140674 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A155E9Y3
• Locus tag: HV150_RS00720
• Protein ID: WP_032675741.1
• Coordinates: 140689..141096 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV150_RS00700	136921..138459	+	1539	WP_023345218.1	aldehyde dehydrogenase AldB	-
HV150_RS00705	138456..139418	-	963	WP_008502735.1	LysR family transcriptional regulator	-
HV150_RS00710	139539..140279	+	741	WP_106105234.1	MipA/OmpV family protein	-
HV150_RS00715	140489..140674	+	186	WP_106105233.1	type II toxin-antitoxin system HicA family toxin	Toxin
HV150_RS00720	140689..141096	+	408	WP_032675741.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HV150_RS00725	141100..142176	-	1077	WP_032654523.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
HV150_RS00730	142522..143217	-	696	WP_023345219.1	L-ribulose-5-phosphate 4-epimerase	-
HV150_RS00735	143211..144071	-	861	WP_106105232.1	L-ribulose-5-phosphate 3-epimerase	-
HV150_RS00740	144074..144727	-	654	WP_106105231.1	3-keto-L-gulonate-6-phosphate decarboxylase UlaD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6941.13 Da
• Isoelectric Point: 11.4904

>T164057 WP_106105233.1 NZ_CP056737:140489-140674 [Enterobacter roggenkampii]
VKSADVITVLISHGWKCVRTKGSHHQFRHPEQKGLVTVRHPKKDIKPGTLAQIWRQAGIKH

Nucleotide

• Length: 186 bp

>T164057 NZ_CP072790:368512-368937 [Mycobacterium tuberculosis]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15010.78 Da
• Isoelectric Point: 4.3897

>AT164057 WP_032675741.1 NZ_CP056737:140689-141096 [Enterobacter roggenkampii]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDNALPLPGNVEAHLESRPEDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPG

Nucleotide

• Length: 408 bp

>AT164057 NZ_CP072790:368294-368515 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A155E9Y3