Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4731814..4732430 Replicon chromosome
Accession NZ_CP056727
Organism Enterobacter hormaechei strain RHBSTW-00316

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV155_RS22755 Protein ID WP_080339264.1
Coordinates 4731814..4732185 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag HV155_RS22760 Protein ID WP_023298920.1
Coordinates 4732188..4732430 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV155_RS22740 4729314..4730216 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
HV155_RS22745 4730213..4730848 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
HV155_RS22750 4730845..4731774 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
HV155_RS22755 4731814..4732185 - 372 WP_080339264.1 type II toxin-antitoxin system VapC family toxin Toxin
HV155_RS22760 4732188..4732430 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
HV155_RS22765 4732630..4733550 + 921 WP_045620872.1 alpha/beta hydrolase -
HV155_RS22770 4733559..4734500 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
HV155_RS22775 4734545..4734982 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV155_RS22780 4734979..4735860 - 882 WP_023298923.1 virulence factor BrkB family protein -
HV155_RS22785 4735854..4736453 - 600 WP_045620871.1 glucose-1-phosphatase -
HV155_RS22790 4736572..4737372 - 801 WP_023298924.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13596.66 Da        Isoelectric Point: 6.4866

>T164053 WP_080339264.1 NZ_CP056727:c4732185-4731814 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T164053 NZ_CP072789:c2699579-2699178 [Geobacter sulfurreducens]
ATGAAATTGCTTCTCGACACCAATATCTGCATTTACATCATAAAGCAGCAGCCGGTTGCTGTACTTGAGCGTTTCTTAGA
GTACCAGGTTGGCGATATTGGCATTTCATCCATAACTCTCTCGGAATTGCGCTACGGAGTTGCGAAGAGCACCCATATGG
AGAAAAACGCCAAGGCCCTCGACGAATTCATCATTCCTTTGGAATTGGTTTCTTATGATGAATCGGCGGCTCATGTCTAT
GGAGATATTCGAGCAGCTCTTGAAAAAGCTGGTACGCCCATTGGCTCCATGGATATGTTGATTGCCGCTCACGCTGTATC
GTTAGGAATCCCTCTGGTCACTAATAACACCCGCGAGTTTTTACGGGTCCCTTCCCTCAATATCATTGATTGGACGGTTT
AG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT164053 WP_023298920.1 NZ_CP056727:c4732430-4732188 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT164053 NZ_CP072789:c2699806-2699579 [Geobacter sulfurreducens]
ATGAAAACTGCAAAGATTTTTCAAAATGGACAAAGTCAGGCAGTAAGGCTTCCCAAAGAATTTCGCTTCGAAGACAGCGA
AGTATTCATCAAGAAAAGCGGCAACGTCGTTCAACTGATCCCTCGGAGCGATTCGTGGAATTCCCTCTTCGGCAGTCTCA
AGAAATTCTCCCGCGATTTCATGTCCGAGCGCATACAACCTGAACTGGACAAGCGGGATGGCTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References