Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4856022..4856638 Replicon chromosome
Accession NZ_CP056719
Organism Enterobacter hormaechei strain RHBSTW-00333

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV163_RS23860 Protein ID WP_080339264.1
Coordinates 4856022..4856393 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag HV163_RS23865 Protein ID WP_023298920.1
Coordinates 4856396..4856638 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV163_RS23845 4853522..4854424 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
HV163_RS23850 4854421..4855056 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
HV163_RS23855 4855053..4855982 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
HV163_RS23860 4856022..4856393 - 372 WP_080339264.1 type II toxin-antitoxin system VapC family toxin Toxin
HV163_RS23865 4856396..4856638 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
HV163_RS23870 4856838..4857758 + 921 WP_045620872.1 alpha/beta hydrolase -
HV163_RS23875 4857767..4858708 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
HV163_RS23880 4858753..4859190 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV163_RS23885 4859187..4860068 - 882 WP_023298923.1 virulence factor BrkB family protein -
HV163_RS23890 4860062..4860661 - 600 WP_045620871.1 glucose-1-phosphatase -
HV163_RS23895 4860780..4861580 - 801 WP_023298924.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13596.66 Da        Isoelectric Point: 6.4866

>T164037 WP_080339264.1 NZ_CP056719:c4856393-4856022 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T164037 NZ_CP072787:1162970-1163368 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT164037 WP_023298920.1 NZ_CP056719:c4856638-4856396 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT164037 NZ_CP072787:1162674-1162967 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAACTGGTTAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References