Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4447202..4447882 Replicon chromosome
Accession NZ_CP056717
Organism Citrobacter sp. RHBSTW-00599

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HV243_RS21615 Protein ID WP_181603875.1
Coordinates 4447202..4447522 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HV243_RS21620 Protein ID WP_181603876.1
Coordinates 4447559..4447882 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV243_RS21585 4442848..4443210 + 363 WP_019078284.1 endoribonuclease SymE -
HV243_RS21590 4443273..4443758 - 486 WP_016151545.1 type VI secretion system tube protein Hcp -
HV243_RS21595 4443777..4444103 - 327 WP_016155588.1 DUF1493 family protein -
HV243_RS21600 4444097..4444546 - 450 WP_003830103.1 hypothetical protein -
HV243_RS21605 4444805..4445677 + 873 WP_081000487.1 HNH endonuclease -
HV243_RS21610 4446160..4446852 + 693 WP_181603874.1 hypothetical protein -
HV243_RS21615 4447202..4447522 - 321 WP_181603875.1 TA system toxin CbtA family protein Toxin
HV243_RS21620 4447559..4447882 - 324 WP_181603876.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV243_RS21625 4447895..4448365 - 471 WP_181603877.1 DNA repair protein RadC -
HV243_RS21630 4448434..4449255 - 822 WP_181603878.1 DUF945 domain-containing protein -
HV243_RS21635 4449405..4450361 - 957 WP_181603879.1 hypothetical protein -
HV243_RS21640 4450905..4451552 + 648 WP_181603880.1 inovirus Gp2 family protein -
HV243_RS21645 4451644..4451862 + 219 WP_181603881.1 AlpA family phage regulatory protein -
HV243_RS21650 4452082..4452870 - 789 WP_181603882.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4444097..4470155 26058


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-105)

Antitoxin

Antitoxin CbeA

(8-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12025.79 Da        Isoelectric Point: 6.3228

>T164023 WP_181603875.1 NZ_CP056717:c4447522-4447202 [Citrobacter sp. RHBSTW-00599]
MHISSVPTTVPVSSRLSPVLVWRQLLTYLLEHHYGLTLNDTPFHDDAAIQEHIEAGITLADGVNFLVERYELVRIDRKGF
TWQEQTPFLTAIDILKAKRATGLINT

Download         Length: 321 bp

>T164023 NZ_CP072786:c2805883-2805781 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12172.95 Da        Isoelectric Point: 5.6291

>AT164023 WP_181603876.1 NZ_CP056717:c4447882-4447559 [Citrobacter sp. RHBSTW-00599]
MPFIPPYEWGLQSDITPRFGARLVQERNCLHYLADRAELTGEFTPKQLQKLDQAFPLFISQLEAMLRSGELNPQQQHQVT
IQLASLTCIADTRGSCGYVYISIYPTP

Download         Length: 324 bp

>AT164023 NZ_CP072786:2805743-2806011 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCTAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References