Detailed information of TA system TA164010

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 796613..797452
• Replicon: chromosome
• Accession: NZ_CP056717
• Organism: Citrobacter sp. RHBSTW-00599

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HV243_RS03835
• Protein ID: WP_040063377.1
• Coordinates: 796613..796990 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HV243_RS03840
• Protein ID: WP_077249796.1
• Coordinates: 797039..797452 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV243_RS03805	791967..792434	-	468	WP_047358704.1	hypothetical protein	-
HV243_RS03810	792434..793009	-	576	WP_081000505.1	S-type pyocin domain-containing protein	-
HV243_RS03815	792970..794211	-	1242	WP_053390097.1	S-type pyocin domain-containing protein	-
HV243_RS03820	794972..795820	-	849	WP_040229927.1	DUF4942 domain-containing protein	-
HV243_RS03825	795901..796095	-	195	WP_047661001.1	DUF957 domain-containing protein	-
HV243_RS03830	796125..796616	-	492	WP_040063379.1	hypothetical protein	-
HV243_RS03835	796613..796990	-	378	WP_040063377.1	TA system toxin CbtA family protein	Toxin
HV243_RS03840	797039..797452	-	414	WP_077249796.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV243_RS03845	797421..797642	-	222	WP_038633763.1	DUF987 domain-containing protein	-
HV243_RS03850	797654..798181	-	528	WP_077249797.1	DNA repair protein RadC	-
HV243_RS03855	798192..798668	-	477	WP_047661000.1	antirestriction protein	-
HV243_RS03860	798665..798928	-	264	WP_038633754.1	hypothetical protein	-
HV243_RS03865	798928..799746	-	819	WP_001234374.1	DUF945 domain-containing protein	-
HV243_RS03870	799862..800112	-	251	Protein_760	DUF905 family protein	-
HV243_RS03875	800303..800770	-	468	WP_000727137.1	hypothetical protein	-
HV243_RS03880	800867..801268	-	402	WP_047660999.1	hypothetical protein	-
HV243_RS03885	801474..802361	-	888	WP_047661008.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	762020..811975	49955

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (33-132)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14020.87 Da
• Isoelectric Point: 6.8604

>T164010 WP_040063377.1 NZ_CP056717:c796990-796613 [Citrobacter sp. RHBSTW-00599]
MQTQPVSPAREASPRLSPVEIWQRLLSHLLDHHYGLALNDTPFGNDDVIQEHIDAGISLCDAVNFIVEKYDLVRTDRYGS
STTEQSPLISSIDILRARKACGLMTRNGYRAVTDITTGKYSKMTR

Nucleotide

• Length: 378 bp

>T164010 NZ_CP072785:c4809639-4809532 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15178.32 Da
• Isoelectric Point: 7.7885

>AT164010 WP_077249796.1 NZ_CP056717:c797452-797039 [Citrobacter sp. RHBSTW-00599]
MSFCAASPSVNSYSRSTTLLNKTLPANHHISEPWWGLKRNITPCFGARLVQEGNRLHYLADRASITGTFTDADLRHLDQA
FPVLLKQMELMLVSGELSPRHQHCVTLYAKGLTCEADSLGSHGYIYIAIYPTPSVTS

Nucleotide

• Length: 414 bp

>AT164010 NZ_CP072785:4809696-4809751 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT