Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 67730..68449 Replicon chromosome
Accession NZ_CP056717
Organism Citrobacter sp. RHBSTW-00599

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HV243_RS00320 Protein ID WP_181603900.1
Coordinates 67730..68050 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HV243_RS00325 Protein ID WP_181603901.1
Coordinates 68084..68449 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV243_RS00300 62963..65797 + 2835 WP_053389775.1 intestinal colonization autotransporter adhesin MisL -
HV243_RS00305 65895..66227 - 333 WP_053389776.1 DUF1493 family protein -
HV243_RS00310 66524..66814 - 291 WP_047415746.1 SymE family type I addiction module toxin -
HV243_RS00315 66951..67142 + 192 WP_003844491.1 toxin-antitoxin system HicB family antitoxin -
HV243_RS00320 67730..68050 - 321 WP_181603900.1 TA system toxin CbtA family protein Toxin
HV243_RS00325 68084..68449 - 366 WP_181603901.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV243_RS00330 68481..68702 - 222 WP_181603902.1 DUF987 family protein -
HV243_RS00335 68711..69181 - 471 WP_181603903.1 DNA repair protein RadC -
HV243_RS00340 69251..70072 - 822 WP_181603904.1 DUF945 domain-containing protein -
HV243_RS00345 70762..71601 - 840 WP_023303145.1 hypothetical protein -
HV243_RS00350 71660..72094 - 435 WP_181603905.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-104)

Antitoxin

Antitoxin CbeA

(18-116)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12169.84 Da        Isoelectric Point: 5.9559

>T164009 WP_181603900.1 NZ_CP056717:c68050-67730 [Citrobacter sp. RHBSTW-00599]
MHISTVPATVTVSSRLSPVQIWQKLLTYLLEHHYGLTINDTPFSNDTAILEHLEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWLTPLDVHRAQFNLGLKRS

Download         Length: 321 bp

>T164009 NZ_CP072785:4389211-4389675 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13413.01 Da        Isoelectric Point: 5.0350

>AT164009 WP_181603901.1 NZ_CP056717:c68449-68084 [Citrobacter sp. RHBSTW-00599]
MQSTTLSDTSAENATCLQWGLKRNITPCFGARLVQEGNHLYFLADRAGFNGSFSDDEALSLDQAFPLMTKQLERMLTTGE
LDTRSQHCVTLHHNGLTCEADTLGSYGYVYIAIYPQSAITR

Download         Length: 366 bp

>AT164009 NZ_CP072785:4388876-4389211 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References