Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3843717..3844374 Replicon chromosome
Accession NZ_CP056716
Organism Enterobacter asburiae strain RHBSTW-00516

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag HV228_RS18855 Protein ID WP_021242050.1
Coordinates 3843717..3844127 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag HV228_RS18860 Protein ID WP_010435322.1
Coordinates 3844108..3844374 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV228_RS18835 3839710..3841443 - 1734 WP_181593808.1 single-stranded-DNA-specific exonuclease RecJ -
HV228_RS18840 3841449..3842162 - 714 WP_181593809.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV228_RS18845 3842191..3843087 - 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
HV228_RS18850 3843189..3843710 + 522 WP_181593810.1 flavodoxin FldB -
HV228_RS18855 3843717..3844127 - 411 WP_021242050.1 protein YgfX Toxin
HV228_RS18860 3844108..3844374 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
HV228_RS18865 3844669..3845649 + 981 WP_181593811.1 tRNA-modifying protein YgfZ -
HV228_RS18870 3845723..3846382 - 660 WP_126796286.1 hemolysin III family protein -
HV228_RS18875 3846548..3846859 - 312 WP_033146592.1 N(4)-acetylcytidine aminohydrolase -
HV228_RS18880 3846911..3847642 + 732 WP_032660101.1 MurR/RpiR family transcriptional regulator -
HV228_RS18885 3847759..3849192 + 1434 WP_181593812.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T164007 WP_021242050.1 NZ_CP056716:c3844127-3843717 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T164007 NZ_CP072785:c3997367-3996960 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT164007 WP_010435322.1 NZ_CP056716:c3844374-3844108 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164007 NZ_CP072785:c3997614-3997348 [Escherichia coli]
ATGGACATTAATAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References