Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3297001..3297740 Replicon chromosome
Accession NZ_CP056716
Organism Enterobacter asburiae strain RHBSTW-00516

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag HV228_RS16130 Protein ID WP_013087269.1
Coordinates 3297001..3297486 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag HV228_RS16135 Protein ID WP_007869691.1
Coordinates 3297474..3297740 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV228_RS16110 3293373..3293570 + 198 WP_035896695.1 hypothetical protein -
HV228_RS16115 3293807..3294556 + 750 WP_004187033.1 phosphate-starvation-inducible PsiE family protein -
HV228_RS16120 3294543..3295505 + 963 WP_004152113.1 M48 family metalloprotease -
HV228_RS16125 3295646..3296847 + 1202 Protein_3159 IS3 family transposase -
HV228_RS16130 3297001..3297486 - 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
HV228_RS16135 3297474..3297740 - 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
HV228_RS16140 3297914..3298611 - 698 Protein_3162 IS1 family transposase -
HV228_RS16145 3298644..3299186 + 543 WP_181595205.1 VWA domain-containing protein -
HV228_RS16150 3299209..3299850 + 642 WP_000116681.1 TerD family protein -
HV228_RS16155 3299850..3300488 + 639 WP_013087240.1 VWA domain-containing protein -
HV228_RS16160 3300574..3301614 + 1041 WP_045899550.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3295820..3298611 2791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T164006 WP_013087269.1 NZ_CP056716:c3297486-3297001 [Enterobacter asburiae]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T164006 NZ_CP072785:c3831712-3831377 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT164006 WP_007869691.1 NZ_CP056716:c3297740-3297474 [Enterobacter asburiae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT164006 NZ_CP072785:c3831960-3831712 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References