Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 247961..248557 Replicon chromosome
Accession NZ_CP056716
Organism Enterobacter asburiae strain RHBSTW-00516

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HV228_RS01190 Protein ID WP_181594182.1
Coordinates 248255..248557 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A2U3EU24
Locus tag HV228_RS01185 Protein ID WP_045355285.1
Coordinates 247961..248248 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV228_RS01180 246333..247964 + 1632 WP_181594181.1 Na/Pi cotransporter family protein -
HV228_RS01185 247961..248248 - 288 WP_045355285.1 putative addiction module antidote protein Antitoxin
HV228_RS01190 248255..248557 - 303 WP_181594182.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV228_RS01195 248755..249627 + 873 WP_023309993.1 23S rRNA pseudouridine(2604) synthase RluF -
HV228_RS01200 249628..249900 - 273 WP_023309994.1 DUF3811 domain-containing protein -
HV228_RS01205 249951..250895 - 945 WP_029740629.1 ketopantoate/pantoate/pantothenate transporter PanS -
HV228_RS01210 250989..252338 - 1350 WP_181594183.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11415.20 Da        Isoelectric Point: 9.6038

>T163995 WP_181594182.1 NZ_CP056716:c248557-248255 [Enterobacter asburiae]
MKEIVQTESFQRWEQNLKDRRAKTIIASRLFRLANGLAGDIKPLGEGISELRIHYGPGYRIYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T163995 NZ_CP072785:c849666-849514 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10101.55 Da        Isoelectric Point: 6.4596

>AT163995 WP_045355285.1 NZ_CP056716:c248248-247961 [Enterobacter asburiae]
MHKLTSYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKHAGD

Download         Length: 288 bp

>AT163995 NZ_CP072785:849715-849772 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2U3EU24

References