Detailed information of TA system TA163979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 569222..569738
• Replicon: chromosome
• Accession: NZ_CP056711
• Organism: Enterobacter asburiae strain RHBSTW-00542

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HV233_RS02855
• Protein ID: WP_023310189.1
• Coordinates: 569454..569738 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V3EXX3
• Locus tag: HV233_RS02850
• Protein ID: WP_008501400.1
• Coordinates: 569222..569464 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV233_RS02835	565219..565959	+	741	WP_045355655.1	KDGP aldolase family protein	-
HV233_RS02840	566075..567211	+	1137	WP_045355656.1	lactonase family protein	-
HV233_RS02845	567234..569144	+	1911	WP_045355657.1	BglG family transcription antiterminator	-
HV233_RS02850	569222..569464	+	243	WP_008501400.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HV233_RS02855	569454..569738	+	285	WP_023310189.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV233_RS02860	569742..570206	-	465	WP_045355659.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HV233_RS02865	570354..572492	-	2139	WP_045355660.1	anaerobic ribonucleoside-triphosphate reductase	-
HV233_RS02870	572869..574512	-	1644	WP_045355661.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10908.82 Da
• Isoelectric Point: 10.2016

>T163979 WP_023310189.1 NZ_CP056711:569454-569738 [Enterobacter asburiae]
MTYELAFDPRALKEWCKLGQTVKDLFKKKLADVLVNPRVESARLHGLPDCYKIKLRTQGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T163979 NZ_CP072784:2024507-2024881 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8972.37 Da
• Isoelectric Point: 5.0651

>AT163979 WP_008501400.1 NZ_CP056711:569222-569464 [Enterobacter asburiae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT163979 NZ_CP072784:2024086-2024460 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Structures

Antitoxin

• AlphaFold DB: V3EXX3