Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 2983659..2985442 Replicon chromosome
Accession NZ_CP056707
Organism Enterobacter hormaechei strain RHBSTW-00564

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HV236_RS14265 Protein ID WP_047053382.1
Coordinates 2983659..2985008 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HV236_RS14270 Protein ID WP_047053381.1
Coordinates 2985005..2985442 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV236_RS14240 2979482..2980417 - 936 WP_003859306.1 tRNA dihydrouridine(16) synthase DusC -
HV236_RS14245 2980586..2980981 + 396 WP_023295055.1 CidA/LrgA family protein -
HV236_RS14250 2980978..2981673 + 696 WP_015572322.1 CidB/LrgB family autolysis modulator -
HV236_RS14255 2981802..2982686 + 885 WP_047053384.1 cytidine deaminase -
HV236_RS14260 2982814..2983524 + 711 WP_003859314.1 outer membrane permeability protein SanA -
HV236_RS14265 2983659..2985008 + 1350 WP_047053382.1 type II toxin-antitoxin system HipA family toxin Toxin
HV236_RS14270 2985005..2985442 + 438 WP_047053381.1 helix-turn-helix domain-containing protein Antitoxin
HV236_RS14275 2985481..2986491 - 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
HV236_RS14280 2986507..2988027 - 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
HV236_RS14285 2988107..2989105 - 999 WP_017383382.1 galactose/glucose ABC transporter substrate-binding protein MglB -
HV236_RS14290 2989401..2990423 - 1023 WP_047053378.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-129)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51132.76 Da        Isoelectric Point: 4.6556

>T163973 WP_047053382.1 NZ_CP056707:2983659-2985008 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLTCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFHYIPDKLSRWGLL

Download         Length: 1350 bp

>T163973 NZ_CP072784:c767924-767586 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCTCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCAAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTGATTAG
TAGCAAAACGCCACGCTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16161.57 Da        Isoelectric Point: 10.5154

>AT163973 WP_047053381.1 NZ_CP056707:2985005-2985442 [Enterobacter hormaechei]
MKTSNEAESELLQTLAQVRSVNKKRHHDEAEDPDKPSVVKRQRVSQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADIINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp

>AT163973 NZ_CP072784:767942-767995 [Escherichia coli]
AATAGGGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References