Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2278267..2279006 Replicon chromosome
Accession NZ_CP056707
Organism Enterobacter hormaechei strain RHBSTW-00564

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HV236_RS10995 Protein ID WP_045329830.1
Coordinates 2278267..2278752 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HV236_RS11000 Protein ID WP_047050951.1
Coordinates 2278740..2279006 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV236_RS10975 2274420..2275178 - 759 WP_047050948.1 trans-aconitate 2-methyltransferase -
HV236_RS10980 2275263..2275847 - 585 WP_047050949.1 NUDIX domain-containing protein -
HV236_RS10985 2275934..2276692 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
HV236_RS10990 2276797..2278089 + 1293 WP_047050950.1 glycoside hydrolase -
HV236_RS10995 2278267..2278752 - 486 WP_045329830.1 GNAT family N-acetyltransferase Toxin
HV236_RS11000 2278740..2279006 - 267 WP_047050951.1 DUF1778 domain-containing protein Antitoxin
HV236_RS11005 2279070..2279999 - 930 WP_047050986.1 LysR family transcriptional regulator -
HV236_RS11010 2280129..2281517 + 1389 WP_181522273.1 MFS transporter -
HV236_RS11015 2281539..2282534 - 996 WP_047050954.1 DUF2891 domain-containing protein -
HV236_RS11020 2282544..2283530 - 987 WP_047050955.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17512.18 Da        Isoelectric Point: 9.9658

>T163963 WP_045329830.1 NZ_CP056707:c2278752-2278267 [Enterobacter hormaechei]
VGRVTAPEPLSSAHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T163963 NZ_CP072779:c3793078-3792659 [Proteus mirabilis]
GTGAAAAAAGTCTATATGCTTGATACAAACATTTGTTCTTTTATCATGCGTGAGCAACCTATTTCTTTGCTCGAAAAACT
TCAGAAATGTGTAATGAACCACGATACTATTGTCATATCAGCGATTACTTATTCAGAGATGCGCTTTGGAGCAATAGGAA
AAAAAGCATCACCTAAACACAATCGTTTGGTTGATGCTTTCTGTGAACGCGTTGACGCGATTTTGGCATGGGATAAAGCG
GCGGTAGACGCAACTACCGTGATAAAAAAATGCTTATCTGATGTGGGATTGCCCATAGGAAATAATGATAGCGCGATTGC
TGGTCATGCTGTCGCGGTTAATGCAATATTGGTAACAAATAATACCCGTGAATTTTCACGAGTTGAAGGACTAAAAATAG
AGGACTGGACTCATGTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10089.51 Da        Isoelectric Point: 4.4857

>AT163963 WP_047050951.1 NZ_CP056707:c2279006-2278740 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVANDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT163963 NZ_CP072779:c3793308-3793075 [Proteus mirabilis]
ATGAGAACGAGAACTGTAGCTGTATTTAAAAACGGAAGTAACCGAGCCATTCGCTTACCTAAAGATTTCGATTTTGATGG
TGTCAATGAACTCGAGATAAGCCGAGATGGGGATTGTATTATTTTACGCCCTGTAAAACCTAACTGGATTTCATTACAAA
ACGAAGAAAAAGCCGACAGTGATTTCTTGCTTGAACGCGATGATGTTATTGAAGAAGGACGAGTTATTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References