Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1704548..1705345 Replicon chromosome
Accession NZ_CP056707
Organism Enterobacter hormaechei strain RHBSTW-00564

Toxin (Protein)


Gene name KacT Uniprot ID A0A4Q2R3N2
Locus tag HV236_RS08145 Protein ID WP_032670168.1
Coordinates 1704824..1705345 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID F5RT92
Locus tag HV236_RS08140 Protein ID WP_001303459.1
Coordinates 1704548..1704817 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV236_RS08110 1700088..1700447 + 360 WP_040117469.1 helix-turn-helix transcriptional regulator -
HV236_RS08115 1700773..1702014 + 1242 WP_047051685.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
HV236_RS08120 1702047..1702274 - 228 WP_006809324.1 YccJ family protein -
HV236_RS08125 1702293..1702889 - 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
HV236_RS08130 1703281..1703451 + 171 WP_001273664.1 general stress protein -
HV236_RS08135 1703568..1704473 + 906 WP_047051684.1 DMT family transporter -
HV236_RS08140 1704548..1704817 + 270 WP_001303459.1 DUF1778 domain-containing protein Antitoxin
HV236_RS08145 1704824..1705345 + 522 WP_032670168.1 GNAT family N-acetyltransferase Toxin
HV236_RS08150 1705404..1706726 - 1323 WP_048982825.1 pyrimidine utilization transport protein G -
HV236_RS08155 1706748..1707239 - 492 WP_047052688.1 pyrimidine utilization flavin reductase protein F -
HV236_RS08160 1707252..1707842 - 591 WP_047052687.1 malonic semialdehyde reductase -
HV236_RS08165 1707852..1708652 - 801 WP_047052686.1 pyrimidine utilization protein D -
HV236_RS08170 1708660..1709046 - 387 WP_032670161.1 pyrimidine utilization protein C -
HV236_RS08175 1709058..1709747 - 690 WP_047052685.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19437.18 Da        Isoelectric Point: 7.4318

>T163962 WP_032670168.1 NZ_CP056707:1704824-1705345 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLVRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp

>T163962 NZ_CP072779:3390956-3391279 [Proteus mirabilis]
ATGAGCTGGAAGATCGACTTTTACGATGGCGTTGAGGAGCAGATCCTCGATATGCCACCCAAAATACAAGCTCGCATGAT
TAAGCTTTTAGAGCTGATGGAAAAGCATGGTGCAAACTTGGGGCCTCCTCATACTGAGTCTATGGGCGATGGGTTATTTG
AAATCCGCGCCAAAGCTCAAGAAGGTATTGGTAGAGGCTTATTTTGCTACTTAAAAGGGAAGCACATTTATGTGTTACAC
GCTTTTGTAAAAAAATCTCAAAAGACGCCCAAAATTGAGCTCAATCTTGCCAGAGATAGACAAAAAGAGGTTCAAAAATC
ATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10248.70 Da        Isoelectric Point: 5.8836

>AT163962 WP_001303459.1 NZ_CP056707:1704548-1704817 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp

>AT163962 NZ_CP072779:3391276-3391554 [Proteus mirabilis]
ATGAGTCTGCAAAAACTGAAACAACGTGCTTTAGCCAATGCTGAAGTTAAAAATGAGTACGATAAGCTTGAGAGTGAGTT
CAGCTTTATTGACCAATTGCTTACCATGAGAACAAAGGCAGGACTTACTCAAGAGCAGGTTGCTGAAAGAATGCATACCC
AAAAAAGTAATGTCAGTCGTTTAGAAAAAGGTAATGCCAATCCAAGTTGGTCAACTCTTCTAAAGTATGCTCACGCATGT
GGCTTTGAACTAACACTCAAGCCACAAAAAATGAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q2R3N2

Antitoxin

Source ID Structure
AlphaFold DB A0A7D7BCZ2

References