Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1089076..1089696 Replicon chromosome
Accession NZ_CP056707
Organism Enterobacter hormaechei strain RHBSTW-00564

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HV236_RS05230 Protein ID WP_015571250.1
Coordinates 1089076..1089294 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HV236_RS05235 Protein ID WP_006809850.1
Coordinates 1089322..1089696 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV236_RS05200 1085088..1085348 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
HV236_RS05205 1085351..1085491 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV236_RS05210 1085488..1086198 - 711 WP_047051118.1 GNAT family N-acetyltransferase -
HV236_RS05215 1086300..1087760 + 1461 WP_047051117.1 PLP-dependent aminotransferase family protein -
HV236_RS05220 1087732..1088199 - 468 WP_017383209.1 membrane protein -
HV236_RS05225 1088316..1088867 - 552 WP_017694396.1 maltose O-acetyltransferase -
HV236_RS05230 1089076..1089294 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HV236_RS05235 1089322..1089696 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HV236_RS05240 1090206..1093352 - 3147 WP_047051116.1 multidrug efflux RND transporter permease subunit AcrB -
HV236_RS05245 1093375..1094568 - 1194 WP_047051115.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T163960 WP_015571250.1 NZ_CP056707:c1089294-1089076 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T163960 NZ_CP072779:c14982-14599 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACATTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATGATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACCGACAATATGCTGGAAAACTTAACAGTGGAAGCGGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT163960 WP_006809850.1 NZ_CP056707:c1089696-1089322 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT163960 NZ_CP072779:c15200-14979 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCGCTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References