Detailed information of TA system TA163959

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 956636..957345
• Replicon: chromosome
• Accession: NZ_CP056707
• Organism: Enterobacter hormaechei strain RHBSTW-00564

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A7D6YAQ1
• Locus tag: HV236_RS04605
• Protein ID: WP_071886833.1
• Coordinates: 956977..957345 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HV236_RS04600
• Protein ID: WP_047051179.1
• Coordinates: 956636..956956 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV236_RS04565	953232..953936	+	705	WP_047051185.1	WYL domain-containing protein	-
HV236_RS04570	953933..954547	+	615	WP_047051184.1	hypothetical protein	-
HV236_RS04575	954636..955046	+	411	WP_047051183.1	hypothetical protein	-
HV236_RS04580	955123..955359	+	237	WP_047051182.1	DUF905 domain-containing protein	-
HV236_RS04585	955439..955897	+	459	WP_047051181.1	antirestriction protein	-
HV236_RS04590	955906..956388	+	483	WP_075211782.1	DNA repair protein RadC	-
HV236_RS04595	956397..956618	+	222	WP_016243789.1	DUF987 domain-containing protein	-
HV236_RS04600	956636..956956	+	321	WP_047051179.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV236_RS04605	956977..957345	+	369	WP_071886833.1	TA system toxin CbtA family protein	Toxin
HV236_RS04610	957691..958437	-	747	WP_047051178.1	class I SAM-dependent methyltransferase	-
HV236_RS04615	958448..958705	-	258	WP_003863178.1	YjhX family toxin	-
HV236_RS04620	958965..960902	-	1938	WP_047051177.1	bifunctional diguanylate cyclase/phosphodiesterase	-
HV236_RS04625	960920..961414	-	495	WP_047051176.1	oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	945392..957345	11953

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (6-105)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13738.90 Da
• Isoelectric Point: 8.1347

>T163959 WP_071886833.1 NZ_CP056707:956977-957345 [Enterobacter hormaechei]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDQTVIQEHIDAGITLANAVNFLVEKYELVRIDRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSRQ

Nucleotide

• Length: 369 bp

>T163959 NZ_CP072774:2358068-2358805 [Bacillus cereus]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGGGAAATATACACGACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATATGGGGAAAAGATTGGCGCGAAAATT
GTTGTTTTTGAAGCCGCGAAAGAGTTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGGATTATACCAGCAAAAATAGTAAGTGACG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11901.60 Da
• Isoelectric Point: 7.2633

>AT163959 WP_047051179.1 NZ_CP056707:956636-956956 [Enterobacter hormaechei]
MRSNATWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISLMESMLTTGEMNPRHAHCVTLY
RNGFTCEADTLGSCGYLYIVVYPTQS

Nucleotide

• Length: 321 bp

>AT163959 NZ_CP072774:2358918-2359046 [Bacillus cereus]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGGTAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Structures

Toxin

• AlphaFold DB: A0A7D6YAQ1