163949

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5650822..5651432 Replicon chromosome
Accession NZ_CP056701
Organism Klebsiella grimontii strain RHBSTW-00577

Toxin (Protein)


Gene name vapC Uniprot ID A0A9E1GAR7
Locus tag HV240_RS27020 Protein ID WP_049086919.1
Coordinates 5650822..5651196 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HV240_RS27025 Protein ID WP_077253475.1
Coordinates 5651193..5651432 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV240_RS27005 5647977..5648879 + 903 WP_004122548.1 formate dehydrogenase subunit beta -
HV240_RS27010 5648876..5649511 + 636 WP_004132860.1 formate dehydrogenase cytochrome b556 subunit -
HV240_RS27015 5649855..5650784 + 930 WP_004132861.1 formate dehydrogenase accessory protein FdhE -
HV240_RS27020 5650822..5651196 - 375 WP_049086919.1 type II toxin-antitoxin system VapC family toxin Toxin
HV240_RS27025 5651193..5651432 - 240 WP_077253475.1 ribbon-helix-helix domain-containing protein Antitoxin
HV240_RS27030 5651638..5652555 + 918 WP_024360706.1 alpha/beta hydrolase -
HV240_RS27035 5652573..5653514 - 942 WP_004127112.1 fatty acid biosynthesis protein FabY -
HV240_RS27040 5653559..5653996 - 438 WP_004132870.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV240_RS27045 5653993..5654853 - 861 WP_004127107.1 virulence factor BrkB family protein -
HV240_RS27050 5654847..5655446 - 600 WP_004132872.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14111.45 Da        Isoelectric Point: 8.4571

>T163949 WP_049086919.1 NZ_CP056701:c5651196-5650822 [Klebsiella grimontii]
MIKGPALFDTNILIDLFSGRVEAKQVLEAYPPQNAISLITWMEVMVGAKKYHQEHRTRIALSAFNIIDISQDIAERSVNL
RKEYGMKLPDAIILATAQIHRYELVTRNTKDFFGIPGVITPYHL

Download         Length: 375 bp

>T163949 NZ_CP072765:3555359-3555703 [Mycobacterium tuberculosis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9293.49 Da        Isoelectric Point: 4.3142

>AT163949 WP_077253475.1 NZ_CP056701:c5651432-5651193 [Klebsiella grimontii]
MMTGTNMGRILLDLSDDVIKRLEDLKQQRNLPRAELLREAVEQYLERQADTTISNALGIWQGCEEDGVEFERKLREEWQ

Download         Length: 240 bp

>AT163949 NZ_CP072765:3555700-3556029 [Mycobacterium tuberculosis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References