Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 951437..952145 Replicon chromosome
Accession NZ_CP056701
Organism Klebsiella grimontii strain RHBSTW-00577

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag HV240_RS04765 Protein ID WP_098067227.1
Coordinates 951822..952145 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HV240_RS04760 Protein ID WP_098067228.1
Coordinates 951437..951787 (+) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV240_RS04730 946615..947766 - 1152 WP_141522397.1 hypothetical protein -
HV240_RS04735 947864..948757 + 894 WP_098067233.1 50S ribosome-binding GTPase -
HV240_RS04740 949042..949719 + 678 WP_098067232.1 hypothetical protein -
HV240_RS04745 949815..950636 + 822 WP_181512234.1 DUF945 domain-containing protein -
HV240_RS04750 950707..951180 + 474 WP_098067230.1 DNA repair protein RadC -
HV240_RS04755 951195..951416 + 222 WP_098067229.1 DUF987 domain-containing protein -
HV240_RS04760 951437..951787 + 351 WP_098067228.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV240_RS04765 951822..952145 + 324 WP_098067227.1 TA system toxin CbtA family protein Toxin
HV240_RS04770 952513..952863 + 351 WP_004134443.1 transcriptional regulator -
HV240_RS04775 952916..954208 + 1293 WP_004134447.1 arsenic transporter -
HV240_RS04780 954218..954643 + 426 WP_181246968.1 glutaredoxin-dependent arsenate reductase -
HV240_RS04785 954836..954907 + 72 Protein_941 adenylyl-sulfate kinase -
HV240_RS04790 955036..956685 - 1650 WP_024358595.1 OFA family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-106)

Antitoxin

Antitoxin CbeA

(15-115)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12211.05 Da        Isoelectric Point: 6.4617

>T163937 WP_098067227.1 NZ_CP056701:951822-952145 [Klebsiella grimontii]
MNTLPAINQRAVQPYPSPVVVWQMLLARLLEQHYGLTLNDTPFSDEAVIKGHIEAGITLVDAVNSLVEKYELVRVDQRGF
SWQEQAPYLTIVDIMRARRYLGITNRS

Download         Length: 324 bp

>T163937 NZ_CP072765:2873151-2873564 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 12916.67 Da        Isoelectric Point: 5.5068

>AT163937 WP_098067228.1 NZ_CP056701:951437-951787 [Klebsiella grimontii]
MSNKTLTANDDTAEPWWGLSRNVIPCFGARMVQEGNRLHYLADRASITGQFNEADLLHLDQAFPVLLKQVELMLTSGELN
PRHQHCVTLYAKGLTCEADTLGSCGYVYIAIYPTQS

Download         Length: 351 bp

>AT163937 NZ_CP072765:2873603-2873860 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References