Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 902996..903653 Replicon chromosome
Accession NZ_CP056701
Organism Klebsiella grimontii strain RHBSTW-00577

Toxin (Protein)


Gene name cptA Uniprot ID A0A285B9I7
Locus tag HV240_RS04490 Protein ID WP_004134421.1
Coordinates 903243..903653 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag HV240_RS04485 Protein ID WP_004105561.1
Coordinates 902996..903262 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV240_RS04460 898175..899608 - 1434 WP_181512086.1 6-phospho-beta-glucosidase -
HV240_RS04465 899730..900458 - 729 WP_024358621.1 MurR/RpiR family transcriptional regulator -
HV240_RS04470 900509..900820 + 312 WP_004133599.1 N(4)-acetylcytidine aminohydrolase -
HV240_RS04475 900983..901642 + 660 WP_004124978.1 hemolysin III family protein -
HV240_RS04480 901769..902752 - 984 WP_049087337.1 tRNA-modifying protein YgfZ -
HV240_RS04485 902996..903262 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
HV240_RS04490 903243..903653 + 411 WP_004134421.1 protein YgfX Toxin
HV240_RS04495 903662..904183 - 522 WP_004134423.1 flavodoxin FldB -
HV240_RS04500 904305..905201 + 897 WP_004124942.1 site-specific tyrosine recombinase XerD -
HV240_RS04505 905224..905937 + 714 WP_004134425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV240_RS04510 905943..907676 + 1734 WP_004134426.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.86 Da        Isoelectric Point: 10.9455

>T163936 WP_004134421.1 NZ_CP056701:903243-903653 [Klebsiella grimontii]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQE

Download         Length: 411 bp

>T163936 NZ_CP072765:c2859683-2859264 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT163936 WP_004105561.1 NZ_CP056701:902996-903262 [Klebsiella grimontii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT163936 NZ_CP072765:c2859904-2859680 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285B9I7

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References