Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 22081..22749 Replicon plasmid pRHBSTW-00605_3
Accession NZ_CP056699
Organism Escherichia marmotae strain RHBSTW-00605

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HV246_RS24175 Protein ID WP_181479373.1
Coordinates 22543..22749 (-) Length 69 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HV246_RS24170 Protein ID WP_181479372.1
Coordinates 22081..22512 (-) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV246_RS24140 17136..17582 + 447 WP_016262345.1 hypothetical protein -
HV246_RS24145 17572..18189 + 618 WP_016262344.1 hypothetical protein -
HV246_RS24150 18186..20138 + 1953 WP_181479371.1 head protein -
HV246_RS24155 20135..20503 + 369 WP_016262342.1 hypothetical protein -
HV246_RS24160 20534..21286 - 753 WP_121372120.1 DUF3944 domain-containing protein -
HV246_RS24165 21304..21759 - 456 WP_121372119.1 helix-turn-helix transcriptional regulator -
HV246_RS24170 22081..22512 - 432 WP_181479372.1 hypothetical protein Antitoxin
HV246_RS24175 22543..22749 - 207 WP_181479373.1 type II toxin-antitoxin system HicA family toxin Toxin
HV246_RS24180 22753..23922 - 1170 WP_181479374.1 transposase -
HV246_RS24185 24270..25955 + 1686 WP_181479375.1 phage portal protein -
HV246_RS24190 25969..26967 + 999 WP_097452639.1 head processing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..94137 94137
- flank IS/Tn - - 22753..23922 1169


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(13-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-82)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7670.89 Da        Isoelectric Point: 11.5111

>T163934 WP_181479373.1 NZ_CP056699:c22749-22543 [Escherichia marmotae]
VGSLARQGGKQSQFKRWLIQQGAEFRKAPGGGSHQKVNLNGKRSVFPDHGSKEMPEPLRKKIMKDLWL

Download         Length: 207 bp

>T163934 NZ_CP072765:c2405441-2405124 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15656.01 Da        Isoelectric Point: 5.2844

>AT163934 WP_181479372.1 NZ_CP056699:c22512-22081 [Escherichia marmotae]
MFNYPVKLERDDKTGAYVVSCRDLPLFNSVGDSLEEALLEAGYGLVAAVAIEIEERRPVPTGSEPKEGEYVVSLPVLPAM
KAALHNAMIETGTRKAELARKLGKNGTQIDRLLDVEHSSKIETVELALHQLNKNIAVSVTPMR

Download         Length: 432 bp

>AT163934 NZ_CP072765:c2405653-2405438 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References