Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 56678..57303 Replicon plasmid pRHBSTW-00605_2
Accession NZ_CP056698
Organism Escherichia marmotae strain RHBSTW-00605

Toxin (Protein)


Gene name vapC Uniprot ID A0A7L6LHR5
Locus tag HV246_RS23600 Protein ID WP_000911307.1
Coordinates 56905..57303 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D6IDB0
Locus tag HV246_RS23595 Protein ID WP_000450523.1
Coordinates 56678..56905 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV246_RS23590 54359..56545 - 2187 WP_181479339.1 type IV conjugative transfer system coupling protein TraD -
HV246_RS23595 56678..56905 + 228 WP_000450523.1 toxin-antitoxin system antitoxin VapB Antitoxin
HV246_RS23600 56905..57303 + 399 WP_000911307.1 tRNA(fMet)-specific endonuclease VapC Toxin
HV246_RS23605 57565..58302 - 738 WP_000927748.1 complement resistance protein TraT -
HV246_RS23610 58374..59024 - 651 WP_181479340.1 hypothetical protein -
HV246_RS23615 59038..61890 - 2853 WP_181479341.1 conjugal transfer mating pair stabilization protein TraG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..127911 127911


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14974.31 Da        Isoelectric Point: 8.1432

>T163929 WP_000911307.1 NZ_CP056698:56905-57303 [Escherichia marmotae]
MLKFMLDTNICIFTIKNKPAHIRERFNLNSGRMCISSVTVMELVYGAEKSQFPERNLAIIEGFISRLDVLDYDCAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERISGLRLEDWC

Download         Length: 399 bp

>T163929 NZ_CP072765:c2236230-2235670 [Mycobacterium tuberculosis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8398.39 Da        Isoelectric Point: 4.3719

>AT163929 WP_000450523.1 NZ_CP056698:56678-56905 [Escherichia marmotae]
METTVFLSNRSQAVRLPKAVALPEDVKKVDVIAVGRTRIITPAGESWDSWFDGDSVSADFMNDREQPAVQERESF

Download         Length: 228 bp

>AT163929 NZ_CP072765:c2236568-2236227 [Mycobacterium tuberculosis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6LFS1

References