Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4728773..4729608 Replicon chromosome
Accession NZ_CP056697
Organism Escherichia marmotae strain RHBSTW-00605

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W3AJH4
Locus tag HV246_RS22615 Protein ID WP_000854721.1
Coordinates 4728773..4729150 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7W3AJG7
Locus tag HV246_RS22620 Protein ID WP_001389198.1
Coordinates 4729240..4729608 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV246_RS22585 4723965..4725179 + 1215 WP_001165572.1 flagellin lysine-N-methylase -
HV246_RS22590 4725593..4726630 - 1038 WP_181478863.1 virulence RhuM family protein -
HV246_RS22595 4726704..4726829 - 126 Protein_4402 DUF4942 domain-containing protein -
HV246_RS22600 4727152..4727994 - 843 WP_181478864.1 DUF4942 domain-containing protein -
HV246_RS22605 4728079..4728276 - 198 WP_000839239.1 DUF957 domain-containing protein -
HV246_RS22610 4728288..4728776 - 489 WP_181478865.1 hypothetical protein -
HV246_RS22615 4728773..4729150 - 378 WP_000854721.1 TA system toxin CbtA family protein Toxin
HV246_RS22620 4729240..4729608 - 369 WP_001389198.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV246_RS22625 4729688..4729909 - 222 WP_001405861.1 DUF987 domain-containing protein -
HV246_RS22630 4729972..4730448 - 477 WP_001186747.1 RadC family protein -
HV246_RS22635 4730464..4730949 - 486 WP_032270302.1 antirestriction protein -
HV246_RS22640 4731041..4731859 - 819 WP_181478866.1 DUF945 domain-containing protein -
HV246_RS22645 4731950..4732183 - 234 WP_181478867.1 DUF905 family protein -
HV246_RS22650 4732669..4733655 - 987 WP_181478868.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14089.12 Da        Isoelectric Point: 8.2904

>T163923 WP_000854721.1 NZ_CP056697:c4729150-4728773 [Escherichia marmotae]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T163923 NZ_CP072765:c1948991-1948602 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13610.39 Da        Isoelectric Point: 6.3159

>AT163923 WP_001389198.1 NZ_CP056697:c4729608-4729240 [Escherichia marmotae]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT163923 NZ_CP072765:c1949215-1948988 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W3AJH4

Antitoxin

Source ID Structure
AlphaFold DB A0A7W3AJG7

References