Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2169459..2171047 Replicon chromosome
Accession NZ_CP056697
Organism Escherichia marmotae strain RHBSTW-00605

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HV246_RS10255 Protein ID WP_105224335.1
Coordinates 2169725..2171047 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HV246_RS10250 Protein ID WP_001516368.1
Coordinates 2169459..2169725 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV246_RS10235 2166135..2167049 + 915 WP_001516366.1 bestrophin family protein -
HV246_RS10240 2167053..2167811 - 759 WP_061090837.1 trans-aconitate 2-methyltransferase -
HV246_RS10245 2168239..2169195 + 957 WP_000197006.1 hypothetical protein -
HV246_RS10250 2169459..2169725 + 267 WP_001516368.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HV246_RS10255 2169725..2171047 + 1323 WP_105224335.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
HV246_RS10260 2171455..2172312 + 858 WP_181479212.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2168239..2183387 15148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49586.23 Da        Isoelectric Point: 8.5841

>T163917 WP_105224335.1 NZ_CP056697:2169725-2171047 [Escherichia marmotae]
MPKLVTWMNNQRVGELTKLTNGAHTFKYAPEWLTNRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPEDETVTRPIMVWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRMGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKEFGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGSTDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGRKTEIDKIYPRHFLATAKALKFPEVQMHEILSDFARMIP
AALDNVKASLPADFPENVLTAIETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

>T163917 NZ_CP072765:1384541-1384972 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10034.37 Da        Isoelectric Point: 4.5668

>AT163917 WP_001516368.1 NZ_CP056697:2169459-2169725 [Escherichia marmotae]
MMSFPMIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLNLSMTLCDTKNDSPES
TDQQDLEW

Download         Length: 267 bp

>AT163917 NZ_CP072765:1384284-1384544 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References