Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1127776..1128394 Replicon chromosome
Accession NZ_CP056697
Organism Escherichia marmotae strain RHBSTW-00605

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HV246_RS05295 Protein ID WP_001280991.1
Coordinates 1127776..1127994 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7U9DNY0
Locus tag HV246_RS05300 Protein ID WP_000344801.1
Coordinates 1127999..1128394 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV246_RS05260 1123070..1123642 + 573 WP_000779815.1 YbaY family lipoprotein -
HV246_RS05265 1123673..1123984 - 312 WP_000409903.1 MGMT family protein -
HV246_RS05275 1124364..1124717 + 354 WP_000878149.1 DUF1428 domain-containing protein -
HV246_RS05280 1124754..1126304 - 1551 WP_001515896.1 EAL domain-containing protein -
HV246_RS05285 1126468..1126938 - 471 WP_001515897.1 YlaC family protein -
HV246_RS05290 1127053..1127604 - 552 WP_000102537.1 maltose O-acetyltransferase -
HV246_RS05295 1127776..1127994 - 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
HV246_RS05300 1127999..1128394 - 396 WP_000344801.1 Hha toxicity modulator TomB Antitoxin
HV246_RS05305 1128951..1132100 - 3150 WP_001132495.1 multidrug efflux RND transporter permease subunit -
HV246_RS05310 1132123..1133316 - 1194 WP_001515899.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T163908 WP_001280991.1 NZ_CP056697:c1127994-1127776 [Escherichia marmotae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T163908 NZ_CP072765:c753370-752987 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 15393.22 Da        Isoelectric Point: 4.9228

>AT163908 WP_000344801.1 NZ_CP056697:c1128394-1127999 [Escherichia marmotae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSCSNYYNHG

Download         Length: 396 bp

>AT163908 NZ_CP072765:c753620-753465 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DNY0

References