Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 291856..292691 Replicon chromosome
Accession NZ_CP056697
Organism Escherichia marmotae strain RHBSTW-00605

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HV246_RS01315 Protein ID WP_181478926.1
Coordinates 291856..292233 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HV246_RS01320 Protein ID WP_135408432.1
Coordinates 292323..292691 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV246_RS01295 288433..289971 - 1539 WP_001187163.1 lysine decarboxylation/transport transcriptional activator CadC -
HV246_RS01300 290795..291352 - 558 Protein_246 DUF4942 domain-containing protein -
HV246_RS01305 291437..291634 - 198 WP_085975623.1 DUF957 domain-containing protein -
HV246_RS01310 291710..291859 - 150 Protein_248 hypothetical protein -
HV246_RS01315 291856..292233 - 378 WP_181478926.1 type IV toxin-antitoxin system toxin CbtA Toxin
HV246_RS01320 292323..292691 - 369 WP_135408432.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV246_RS01325 292766..292987 - 222 WP_094321593.1 DUF987 domain-containing protein -
HV246_RS01330 293050..293526 - 477 WP_122997478.1 RadC family protein -
HV246_RS01335 293542..294027 - 486 WP_181478927.1 antirestriction protein -
HV246_RS01340 294129..294947 - 819 WP_181478928.1 DUF945 domain-containing protein -
HV246_RS01345 295283..295819 - 537 WP_181478929.1 DUF4234 domain-containing protein -
HV246_RS01350 295882..297183 - 1302 WP_181478930.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 280623..303781 23158


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14176.22 Da        Isoelectric Point: 6.7114

>T163905 WP_181478926.1 NZ_CP056697:c292233-291856 [Escherichia marmotae]
MKTLPVLPGQAASSRLSPVEIWQILLSRLLDQHYGLTLDDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATDLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T163905 NZ_CP072765:711009-711410 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13636.46 Da        Isoelectric Point: 6.4658

>AT163905 WP_135408432.1 NZ_CP056697:c292691-292323 [Escherichia marmotae]
VSDTLPGTTHPDNNNDRPWWGLPCTVMPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT163905 NZ_CP072765:710785-711012 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References