Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3977338..3977995 Replicon chromosome
Accession NZ_CP056691
Organism Enterobacter hormaechei strain RHBSTW-00626

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag HV249_RS19385 Protein ID WP_022649305.1
Coordinates 3977338..3977748 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag HV249_RS19390 Protein ID WP_003863437.1
Coordinates 3977729..3977995 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV249_RS19365 3973336..3975069 - 1734 WP_045308807.1 single-stranded-DNA-specific exonuclease RecJ -
HV249_RS19370 3975075..3975788 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV249_RS19375 3975817..3976713 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
HV249_RS19380 3976815..3977336 + 522 WP_015571793.1 flavodoxin FldB -
HV249_RS19385 3977338..3977748 - 411 WP_022649305.1 protein YgfX Toxin
HV249_RS19390 3977729..3977995 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
HV249_RS19395 3978290..3979270 + 981 WP_045622914.1 tRNA-modifying protein YgfZ -
HV249_RS19400 3979791..3980450 - 660 WP_022649307.1 hemolysin III family protein -
HV249_RS19405 3980717..3981448 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T163901 WP_022649305.1 NZ_CP056691:c3977748-3977338 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T163901 NZ_CP072765:677925-678332 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT163901 WP_003863437.1 NZ_CP056691:c3977995-3977729 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT163901 NZ_CP072765:677713-677928 [Mycobacterium tuberculosis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References