Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1121140..1121761 Replicon chromosome
Accession NZ_CP056691
Organism Enterobacter hormaechei strain RHBSTW-00626

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HV249_RS05425 Protein ID WP_015571250.1
Coordinates 1121140..1121358 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HV249_RS05430 Protein ID WP_006809850.1
Coordinates 1121387..1121761 (-) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV249_RS05395 1117152..1117412 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
HV249_RS05400 1117415..1117555 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV249_RS05405 1117552..1118262 - 711 WP_045622295.1 GNAT family N-acetyltransferase -
HV249_RS05410 1118365..1119825 + 1461 WP_023299463.1 PLP-dependent aminotransferase family protein -
HV249_RS05415 1119797..1120264 - 468 WP_045622293.1 membrane protein -
HV249_RS05420 1120381..1120932 - 552 WP_045622291.1 maltose O-acetyltransferase -
HV249_RS05425 1121140..1121358 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HV249_RS05430 1121387..1121761 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HV249_RS05435 1122271..1125417 - 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
HV249_RS05440 1125440..1126633 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-114)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T163891 WP_015571250.1 NZ_CP056691:c1121358-1121140 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T163891 NZ_CP072764:c3713112-3712684 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT163891 WP_006809850.1 NZ_CP056691:c1121761-1121387 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT163891 NZ_CP072764:c3713358-3713116 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A837FFM2


Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References