Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5861940..5862550 Replicon chromosome
Accession NZ_CP056682
Organism Klebsiella grimontii strain RHBSTW-00634

Toxin (Protein)


Gene name vapC Uniprot ID A0A9E1GAR7
Locus tag HV252_RS27685 Protein ID WP_049086919.1
Coordinates 5861940..5862314 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HV252_RS27690 Protein ID WP_077253475.1
Coordinates 5862311..5862550 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV252_RS27670 5859095..5859997 + 903 WP_004122548.1 formate dehydrogenase subunit beta -
HV252_RS27675 5859994..5860629 + 636 WP_004132860.1 formate dehydrogenase cytochrome b556 subunit -
HV252_RS27680 5860973..5861902 + 930 WP_004132861.1 formate dehydrogenase accessory protein FdhE -
HV252_RS27685 5861940..5862314 - 375 WP_049086919.1 type II toxin-antitoxin system VapC family toxin Toxin
HV252_RS27690 5862311..5862550 - 240 WP_077253475.1 ribbon-helix-helix domain-containing protein Antitoxin
HV252_RS27695 5862756..5863673 + 918 WP_181511613.1 alpha/beta hydrolase -
HV252_RS27700 5863691..5864632 - 942 WP_004127112.1 fatty acid biosynthesis protein FabY -
HV252_RS27705 5864677..5865114 - 438 WP_004132870.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV252_RS27710 5865111..5865971 - 861 WP_004127107.1 virulence factor BrkB family protein -
HV252_RS27715 5865965..5866564 - 600 WP_024360709.1 glucose-1-phosphatase -
HV252_RS27720 5866694..5867479 - 786 WP_064342034.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14111.45 Da        Isoelectric Point: 8.4571

>T163883 WP_049086919.1 NZ_CP056682:c5862314-5861940 [Klebsiella grimontii]
MIKGPALFDTNILIDLFSGRVEAKQVLEAYPPQNAISLITWMEVMVGAKKYHQEHRTRIALSAFNIIDISQDIAERSVNL
RKEYGMKLPDAIILATAQIHRYELVTRNTKDFFGIPGVITPYHL

Download         Length: 375 bp

>T163883 NZ_CP072764:c3075582-3075166 [Mycobacterium tuberculosis]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9293.49 Da        Isoelectric Point: 4.3142

>AT163883 WP_077253475.1 NZ_CP056682:c5862550-5862311 [Klebsiella grimontii]
MMTGTNMGRILLDLSDDVIKRLEDLKQQRNLPRAELLREAVEQYLERQADTTISNALGIWQGCEEDGVEFERKLREEWQ

Download         Length: 240 bp

>AT163883 NZ_CP072764:c3075845-3075579 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References