Detailed information of TA system TA163882

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4777148..4777967
• Replicon: chromosome
• Accession: NZ_CP056682
• Organism: Klebsiella grimontii strain RHBSTW-00634

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A9E1D5M6
• Locus tag: HV252_RS22615
• Protein ID: WP_004132607.1
• Coordinates: 4777710..4777967 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A9E1DGJ5
• Locus tag: HV252_RS22610
• Protein ID: WP_004132606.1
• Coordinates: 4777148..4777699 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV252_RS22595	4772538..4773935	+	1398	WP_004132593.1	MFS transporter	-
HV252_RS22600	4774059..4775399	+	1341	WP_049085654.1	carbohydrate porin	-
HV252_RS22605	4775502..4777130	-	1629	WP_181511900.1	SAM-dependent methyltransferase	-
HV252_RS22610	4777148..4777699	-	552	WP_004132606.1	N-acetyltransferase	Antitoxin
HV252_RS22615	4777710..4777967	-	258	WP_004132607.1	YjhX family toxin	Toxin
HV252_RS22620	4778551..4779735	+	1185	WP_049085652.1	mannonate dehydratase	-
HV252_RS22625	4779812..4781287	+	1476	WP_049130810.1	fructuronate reductase	-
HV252_RS22630	4781424..4782200	+	777	WP_024359123.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (34-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9538.04 Da
• Isoelectric Point: 11.1381

>T163882 WP_004132607.1 NZ_CP056682:c4777967-4777710 [Klebsiella grimontii]
MNLSRQEQRTLHVLAKGGRIAHVRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T163882 NZ_CP072764:c2981905-2981582 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19990.89 Da
• Isoelectric Point: 7.2343

>AT163882 WP_004132606.1 NZ_CP056682:c4777699-4777148 [Klebsiella grimontii]
MTNHSFTFHVASEGDTNDILHVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGKAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGGLIRHGIEQLKAMGSQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEALKACWMLQPLSS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT163882 NZ_CP072764:c2982230-2981985 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA