Detailed information of TA system TA163880

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 4426107..4426896
• Replicon: chromosome
• Accession: NZ_CP056682
• Organism: Klebsiella grimontii strain RHBSTW-00634

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: HV252_RS21000
• Protein ID: WP_181511487.1
• Coordinates: 4426107..4426475 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HV252_RS21005
• Protein ID: WP_181511488.1
• Coordinates: 4426537..4426896 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV252_RS20975	4422241..4422528	+	288	WP_181511485.1	hypothetical protein	-
HV252_RS20980	4422528..4422779	+	252	Protein_4128	hypothetical protein	-
HV252_RS20985	4422846..4423826	+	981	WP_000019441.1	IS5-like element ISKpn26 family transposase	-
HV252_RS20990	4423974..4424621	+	648	Protein_4130	nucleotide-binding protein	-
HV252_RS20995	4424709..4425815	+	1107	WP_181511486.1	hypothetical protein	-
HV252_RS21000	4426107..4426475	-	369	WP_181511487.1	TA system toxin CbtA family protein	Toxin
HV252_RS21005	4426537..4426896	-	360	WP_181511488.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV252_RS21010	4426912..4427394	-	483	WP_181511489.1	DNA repair protein RadC	-
HV252_RS21015	4427407..4427862	-	456	WP_181511490.1	antirestriction protein	-
HV252_RS21020	4427895..4428716	-	822	WP_181511491.1	DUF945 domain-containing protein	-
HV252_RS21025	4429181..4429804	+	624	WP_181511492.1	inovirus Gp2 family protein	-
HV252_RS21030	4429925..4430140	+	216	WP_181511898.1	AlpA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4412671..4449309	36638
	-	flank	IS/Tn	-	-	4422846..4423826	980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (9-112)

Antitoxin

• Antitoxin CbeA (16-114)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13550.47 Da
• Isoelectric Point: 6.2123

>T163880 WP_181511487.1 NZ_CP056682:c4426475-4426107 [Klebsiella grimontii]
MQTSFPAQELAGNICLPPVAVWQTLLAHLLEQHYSLTLNDTPFSNETVIQEHINAGISLADALNFIVEKYELVRTDRPGF
SVSEQAPFITSIDILRARKATGLMKRYSYRAVSNITNSLSGI

Nucleotide

• Length: 369 bp

>T163880 NZ_CP056682:c4426475-4426107 [Klebsiella grimontii]
ATGCAAACCTCATTCCCTGCCCAGGAATTGGCGGGTAACATTTGTCTGCCGCCCGTGGCTGTCTGGCAGACTCTGTTGGC
TCACCTGCTGGAGCAACACTATAGCCTGACGCTGAACGACACGCCGTTCAGTAATGAAACCGTTATTCAGGAACATATTA
ATGCCGGTATTTCGCTGGCGGATGCTTTGAATTTTATTGTTGAGAAATATGAGCTGGTTCGCACTGATCGTCCCGGTTTC
AGTGTCAGCGAACAGGCACCGTTTATCACATCTATTGATATCCTGAGAGCCAGGAAAGCGACAGGACTGATGAAACGCTA
CAGCTATAGAGCGGTGAGCAACATAACCAACAGTTTGTCTGGAATATAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13281.37 Da
• Isoelectric Point: 7.2897

>AT163880 WP_181511488.1 NZ_CP056682:c4426896-4426537 [Klebsiella grimontii]
MKNQSLKDSEKPVNPPWGLQRPVTPLFSTRLVQEGNRLHYLAERASIIGTFSAEDLRHLDQAFPVLLKPMELMLTSGELN
PRHQHCVTLYAKGLTCEADTLGSCGYVYMVIYPTPVPAA

Nucleotide

• Length: 360 bp

>AT163880 NZ_CP056682:c4426896-4426537 [Klebsiella grimontii]
ATGAAGAATCAATCGCTGAAAGACAGTGAAAAACCTGTCAATCCACCGTGGGGACTTCAGCGCCCCGTAACGCCTCTGTT
CAGTACGCGTCTGGTGCAAGAAGGCAACCGGCTACATTATCTCGCTGAGCGGGCCAGTATAATCGGGACATTCAGCGCTG
AGGATTTACGTCACCTCGACCAGGCGTTTCCGGTATTGCTTAAACCGATGGAACTGATGCTGACCAGCGGTGAACTGAAT
CCGCGTCACCAGCACTGCGTTACGCTTTATGCAAAAGGACTAACTTGTGAGGCTGACACTCTCGGTAGCTGCGGTTATGT
TTACATGGTCATTTATCCCACGCCAGTACCTGCCGCATAA