Detailed information of TA system TA163868

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 843288..843945
• Replicon: chromosome
• Accession: NZ_CP056682
• Organism: Klebsiella grimontii strain RHBSTW-00634

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A9E1DA00
• Locus tag: HV252_RS04080
• Protein ID: WP_024358614.1
• Coordinates: 843535..843945 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: H3N295
• Locus tag: HV252_RS04075
• Protein ID: WP_004124953.1
• Coordinates: 843288..843554 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV252_RS04060	838458..838883	-	426	WP_181511673.1	PTS sugar transporter subunit IIA	-
HV252_RS04065	839004..841802	-	2799	WP_181511674.1	transcriptional regulator DagR	-
HV252_RS04070	842060..843043	-	984	WP_181511675.1	tRNA-modifying protein YgfZ	-
HV252_RS04075	843288..843554	+	267	WP_004124953.1	FAD assembly factor SdhE	Antitoxin
HV252_RS04080	843535..843945	+	411	WP_024358614.1	protein YgfX	Toxin
HV252_RS04085	843954..844475	-	522	WP_024358613.1	flavodoxin FldB	-
HV252_RS04090	844597..845493	+	897	WP_004124942.1	site-specific tyrosine recombinase XerD	-
HV252_RS04095	845516..846229	+	714	WP_004134425.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
HV252_RS04100	846235..847968	+	1734	WP_004134426.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16135.97 Da
• Isoelectric Point: 10.9455

>T163868 WP_024358614.1 NZ_CP056682:843535-843945 [Klebsiella grimontii]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWEIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQE

Nucleotide

• Length: 411 bp

>T163868 NZ_CP072764:c2206906-2206610 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10411.88 Da
• Isoelectric Point: 5.1296

>AT163868 WP_004124953.1 NZ_CP056682:843288-843554 [Klebsiella grimontii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT163868 NZ_CP072764:c2207154-2206903 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3H3L9