Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3818628..3819249 Replicon chromosome
Accession NZ_CP056676
Organism Enterobacter hormaechei strain RHBSTW-00642

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HV254_RS18635 Protein ID WP_015571250.1
Coordinates 3819031..3819249 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HV254_RS18630 Protein ID WP_006809850.1
Coordinates 3818628..3819002 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV254_RS18620 3813756..3814949 + 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV254_RS18625 3814972..3818118 + 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
HV254_RS18630 3818628..3819002 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HV254_RS18635 3819031..3819249 + 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HV254_RS18640 3819457..3820008 + 552 WP_045622291.1 maltose O-acetyltransferase -
HV254_RS18645 3820125..3820592 + 468 WP_045622293.1 membrane protein -
HV254_RS18650 3820564..3822024 - 1461 WP_023299463.1 PLP-dependent aminotransferase family protein -
HV254_RS18655 3822127..3822837 + 711 WP_045622295.1 GNAT family N-acetyltransferase -
HV254_RS18660 3822834..3822974 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV254_RS18665 3822977..3823237 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T163861 WP_015571250.1 NZ_CP056676:3819031-3819249 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T163861 NZ_CP072764:c1575877-1575476 [Mycobacterium tuberculosis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGACCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT163861 WP_006809850.1 NZ_CP056676:3818628-3819002 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT163861 NZ_CP072764:c1576131-1575874 [Mycobacterium tuberculosis]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References