Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 14440..15176 Replicon plasmid pRHBSTW-00668_2
Accession NZ_CP056664
Organism Enterobacter hormaechei strain RHBSTW-00668

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag HV259_RS23990 Protein ID WP_003026803.1
Coordinates 14694..15176 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag HV259_RS23985 Protein ID WP_003026799.1
Coordinates 14440..14706 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV259_RS23945 10005..11006 + 1002 WP_032635019.1 Abi family protein -
HV259_RS23950 11145..11723 - 579 WP_032635068.1 hypothetical protein -
HV259_RS23955 12013..12276 + 264 WP_009310051.1 hypothetical protein -
HV259_RS23960 12273..12839 + 567 WP_009310052.1 hypothetical protein -
HV259_RS23965 12870..13364 + 495 WP_053504376.1 hypothetical protein -
HV259_RS23970 13425..13628 + 204 WP_004150739.1 hemolysin expression modulator Hha -
HV259_RS23975 13677..13934 + 258 WP_004098928.1 hypothetical protein -
HV259_RS23980 14010..14264 + 255 WP_016528790.1 hypothetical protein -
HV259_RS23985 14440..14706 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
HV259_RS23990 14694..15176 + 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
HV259_RS23995 15388..16731 + 1344 WP_080339306.1 ISNCY family transposase -
HV259_RS24000 16802..17620 - 819 WP_023307220.1 abortive infection family protein -
HV259_RS24005 17629..18201 - 573 WP_032676095.1 recombinase family protein -
HV259_RS24010 18489..18899 - 411 WP_053504377.1 hypothetical protein -
HV259_RS24015 19055..19495 + 441 WP_023307217.1 IS66 family insertion sequence hypothetical protein -
HV259_RS24020 19492..19842 + 351 WP_004189161.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mrkF / mrkD / mrkC / mrkB / mrkA 1..106339 106339


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T163851 WP_003026803.1 NZ_CP056664:14694-15176 [Enterobacter hormaechei]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

>T163851 NZ_CP072764:c755775-755338 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT163851 WP_003026799.1 NZ_CP056664:14440-14706 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT163851 NZ_CP072764:c755228-754983 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References