Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4835158..4835774 Replicon chromosome
Accession NZ_CP056663
Organism Enterobacter hormaechei strain RHBSTW-00668

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV259_RS23490 Protein ID WP_080339264.1
Coordinates 4835158..4835529 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag HV259_RS23495 Protein ID WP_023298920.1
Coordinates 4835532..4835774 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV259_RS23475 4832658..4833560 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
HV259_RS23480 4833557..4834192 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
HV259_RS23485 4834189..4835118 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
HV259_RS23490 4835158..4835529 - 372 WP_080339264.1 type II toxin-antitoxin system VapC family toxin Toxin
HV259_RS23495 4835532..4835774 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
HV259_RS23500 4835974..4836894 + 921 WP_045620872.1 alpha/beta hydrolase -
HV259_RS23505 4836903..4837844 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
HV259_RS23510 4837889..4838326 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV259_RS23515 4838323..4839204 - 882 WP_023298923.1 virulence factor BrkB family protein -
HV259_RS23520 4839198..4839797 - 600 WP_045620871.1 glucose-1-phosphatase -
HV259_RS23525 4839916..4840716 - 801 WP_023298924.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13596.66 Da        Isoelectric Point: 6.4866

>T163850 WP_080339264.1 NZ_CP056663:c4835529-4835158 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T163850 NZ_CP072764:c754996-754688 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT163850 WP_023298920.1 NZ_CP056663:c4835774-4835532 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT163850 NZ_CP072764:c755228-754983 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References