Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3972794..3973451 Replicon chromosome
Accession NZ_CP056663
Organism Enterobacter hormaechei strain RHBSTW-00668

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag HV259_RS19285 Protein ID WP_022649305.1
Coordinates 3972794..3973204 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag HV259_RS19290 Protein ID WP_003863437.1
Coordinates 3973185..3973451 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV259_RS19265 3968792..3970525 - 1734 WP_045308807.1 single-stranded-DNA-specific exonuclease RecJ -
HV259_RS19270 3970531..3971244 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV259_RS19275 3971273..3972169 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
HV259_RS19280 3972271..3972792 + 522 WP_015571793.1 flavodoxin FldB -
HV259_RS19285 3972794..3973204 - 411 WP_022649305.1 protein YgfX Toxin
HV259_RS19290 3973185..3973451 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
HV259_RS19295 3973746..3974726 + 981 WP_045622914.1 tRNA-modifying protein YgfZ -
HV259_RS19300 3975247..3975906 - 660 WP_022649307.1 hemolysin III family protein -
HV259_RS19305 3976173..3976904 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T163849 WP_022649305.1 NZ_CP056663:c3973204-3972794 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T163849 NZ_CP072764:c753370-752987 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT163849 WP_003863437.1 NZ_CP056663:c3973451-3973185 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT163849 NZ_CP072764:c753620-753465 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References