Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1085666..1086287 Replicon chromosome
Accession NZ_CP056663
Organism Enterobacter hormaechei strain RHBSTW-00668

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HV259_RS05145 Protein ID WP_015571250.1
Coordinates 1085666..1085884 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HV259_RS05150 Protein ID WP_006809850.1
Coordinates 1085913..1086287 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV259_RS05115 1081678..1081938 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
HV259_RS05120 1081941..1082081 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV259_RS05125 1082078..1082788 - 711 WP_045622295.1 GNAT family N-acetyltransferase -
HV259_RS05130 1082891..1084351 + 1461 WP_023299463.1 PLP-dependent aminotransferase family protein -
HV259_RS05135 1084323..1084790 - 468 WP_045622293.1 membrane protein -
HV259_RS05140 1084907..1085458 - 552 WP_045622291.1 maltose O-acetyltransferase -
HV259_RS05145 1085666..1085884 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HV259_RS05150 1085913..1086287 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HV259_RS05155 1086797..1089943 - 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
HV259_RS05160 1089966..1091159 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T163841 WP_015571250.1 NZ_CP056663:c1085884-1085666 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T163841 NZ_CP072764:c640644-640231 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT163841 WP_006809850.1 NZ_CP056663:c1086287-1085913 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT163841 NZ_CP072764:c640907-640641 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References