Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 763288..764009 Replicon chromosome
Accession NZ_CP056647
Organism Citrobacter sp. RHBSTW-00229

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag HV135_RS03750 Protein ID WP_047399350.1
Coordinates 763668..764009 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HV135_RS03745 Protein ID WP_096252653.1
Coordinates 763288..763632 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV135_RS03715 759647..760081 + 435 WP_115223459.1 hypothetical protein -
HV135_RS03720 760101..760904 + 804 WP_097424880.1 hypothetical protein -
HV135_RS03725 761148..761597 + 450 WP_097424884.1 hypothetical protein -
HV135_RS03730 761668..762489 + 822 WP_096252651.1 DUF945 domain-containing protein -
HV135_RS03735 762559..763032 + 474 WP_096252652.1 DNA repair protein RadC -
HV135_RS03740 763043..763264 + 222 WP_115223461.1 DUF987 family protein -
HV135_RS03745 763288..763632 + 345 WP_096252653.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV135_RS03750 763668..764009 + 342 WP_047399350.1 TA system toxin CbtA family protein Toxin
HV135_RS03755 764124..764957 + 834 WP_115223463.1 DUF4942 domain-containing protein -
HV135_RS03760 765034..765282 + 249 WP_000535212.1 ribbon-helix-helix domain-containing protein -
HV135_RS03765 765286..765561 + 276 WP_001683517.1 type II toxin-antitoxin system RelE/ParE family toxin -
HV135_RS03770 765676..766473 + 798 WP_115223464.1 helix-turn-helix transcriptional regulator -
HV135_RS03775 766769..768028 + 1260 WP_023307467.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(14-113)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12748.67 Da        Isoelectric Point: 8.5196

>T163823 WP_047399350.1 NZ_CP056647:763668-764009 [Citrobacter sp. RHBSTW-00229]
MNTSPATNQRVAKPCPSPVAVWQMLLTRLLAQHYGLALSDTPFCDETVIQEHINAGVTLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQAMGLLRQGHNLSTR

Download         Length: 342 bp

>T163823 NZ_CP072763:c2981906-2981583 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13006.03 Da        Isoelectric Point: 8.4957

>AT163823 WP_096252653.1 NZ_CP056647:763288-763632 [Citrobacter sp. RHBSTW-00229]
MKKDTANEVVDTLRWGLKCDITPHFGARLVQEGNRLHYLADRASIIGQFSKADLRHLNQAFPLLVKQMELMLTSGELNPR
HQHCVTLYAKRLTCEADTLGSCGYVYITIYPTQR

Download         Length: 345 bp

>AT163823 NZ_CP072763:c2982231-2981986 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References