Detailed information of TA system TA163822

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 698662..699181
• Replicon: chromosome
• Accession: NZ_CP056647
• Organism: Citrobacter sp. RHBSTW-00229

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HV135_RS03450
• Protein ID: WP_181221150.1
• Coordinates: 698900..699181 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0V9JX71
• Locus tag: HV135_RS03445
• Protein ID: WP_016155558.1
• Coordinates: 698662..698910 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV135_RS03425	694294..695241	+	948	WP_103766891.1	type VI secretion system baseplate subunit TssG	-
HV135_RS03430	695232..697742	+	2511	WP_181632401.1	type VI secretion system ATPase TssH	-
HV135_RS03435	697752..698372	+	621	WP_181221148.1	hypothetical protein	-
HV135_RS03440	698417..698638	+	222	WP_181221149.1	hypothetical protein	-
HV135_RS03445	698662..698910	+	249	WP_016155558.1	hypothetical protein	Antitoxin
HV135_RS03450	698900..699181	+	282	WP_181221150.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV135_RS03455	699208..701172	+	1965	WP_181221151.1	type VI secretion system tip protein VgrG	-
HV135_RS03460	701172..701693	+	522	WP_181221152.1	hypothetical protein	-
HV135_RS03465	701715..702179	-	465	WP_016155562.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10999.74 Da
• Isoelectric Point: 10.2922

>T163822 WP_181221150.1 NZ_CP056647:698900-699181 [Citrobacter sp. RHBSTW-00229]
MTYNLEFLDVALKEWHKLSPTLREQFKKKLAERLENPHVPAARLSGKLHRYKIKLRSAGYRLIYQVEDEQVVVLVIAVGR
RDGDEVYHQANRR

Nucleotide

• Length: 282 bp

>T163822 NZ_CP072763:2935341-2935781 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8987.28 Da
• Isoelectric Point: 4.7513

>AT163822 WP_016155558.1 NZ_CP056647:698662-698910 [Citrobacter sp. RHBSTW-00229]
MPFHILTKTAASITDLKRNPMGTVNAGEGEAVAILNRNEPAFYCVPPAVYAYLLELAEDAELNRIADEREGGKRIKVSLN
DL

Nucleotide

• Length: 249 bp

>AT163822 NZ_CP072763:2935067-2935354 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0V9JX71