Detailed information of TA system TA163817

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4524776..4525311
• Replicon: chromosome
• Accession: NZ_CP056644
• Organism: Citrobacter freundii strain RHBSTW-00267

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HV139_RS21750
• Protein ID: WP_117343582.1
• Coordinates: 4525024..4525311 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4BKM9
• Locus tag: HV139_RS21745
• Protein ID: WP_006688247.1
• Coordinates: 4524776..4525027 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV139_RS21715	4519789..4520637	+	849	WP_135912711.1	alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ	-
HV139_RS21720	4520634..4521392	+	759	WP_115259672.1	phosphonate C-P lyase system protein PhnK	-
HV139_RS21725	4521500..4522180	+	681	WP_117343579.1	phosphonate C-P lyase system protein PhnL	-
HV139_RS21730	4522177..4523313	+	1137	WP_096758663.1	alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase	-
HV139_RS21735	4523316..4523861	+	546	WP_115259675.1	ribose 1,5-bisphosphokinase	-
HV139_RS21740	4523934..4524692	+	759	WP_181629700.1	phosphonate metabolism protein PhnP	-
HV139_RS21745	4524776..4525027	+	252	WP_006688247.1	plasmid stabilization protein	Antitoxin
HV139_RS21750	4525024..4525311	+	288	WP_117343582.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV139_RS21755	4525308..4525637	-	330	WP_096758667.1	hypothetical protein	-
HV139_RS21760	4525706..4527970	-	2265	WP_181629702.1	hybrid sensor histidine kinase/response regulator	-
HV139_RS21765	4528085..4529608	+	1524	WP_181629704.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11139.00 Da
• Isoelectric Point: 10.2830

>T163817 WP_117343582.1 NZ_CP056644:4525024-4525311 [Citrobacter freundii]
MSYTVKFREDALKEWQKLDKTIQQQLAKELKKCGENPHVPSAKLRGIKDCYKIQLRTSRFRLVYQVIDDTLVIAVVAVGK
RERSEVYNLASERLR

Nucleotide

• Length: 288 bp

>T163817 NZ_CP072763:2813307-2813732 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9215.53 Da
• Isoelectric Point: 4.2965

>AT163817 WP_006688247.1 NZ_CP056644:4524776-4525027 [Citrobacter freundii]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQQLVKLVHERSQQPLVDVDLD
SYL

Nucleotide

• Length: 252 bp

>AT163817 NZ_CP072763:2813080-2813301 [Mycobacterium tuberculosis]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Structures

Antitoxin

• AlphaFold DB: A0A7X1BT32