Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3663856..3664535 Replicon chromosome
Accession NZ_CP056644
Organism Citrobacter freundii strain RHBSTW-00267

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag HV139_RS17650 Protein ID WP_049100280.1
Coordinates 3664194..3664535 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HV139_RS17645 Protein ID WP_023326101.1
Coordinates 3663856..3664173 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV139_RS17600 3659294..3660115 + 822 WP_023326105.1 DUF945 domain-containing protein -
HV139_RS17605 3660332..3661033 + 702 WP_023326104.1 WYL domain-containing protein -
HV139_RS17610 3661074..3661310 + 237 WP_001144031.1 hypothetical protein -
HV139_RS17615 3661310..3661753 + 444 WP_000824223.1 hypothetical protein -
HV139_RS17620 3661776..3662243 + 468 WP_001547765.1 hypothetical protein -
HV139_RS17625 3662320..3662559 + 240 WP_000194654.1 DUF905 domain-containing protein -
HV139_RS17630 3662657..3663115 + 459 WP_000211838.1 antirestriction protein -
HV139_RS17635 3663131..3663607 + 477 WP_000811693.1 RadC family protein -
HV139_RS17640 3663616..3663837 + 222 WP_023326102.1 DUF987 domain-containing protein -
HV139_RS17645 3663856..3664173 + 318 WP_023326101.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV139_RS17650 3664194..3664535 + 342 WP_049100280.1 TA system toxin CbtA family protein Toxin
HV139_RS17655 3664651..3665487 + 837 WP_049100278.1 DUF4942 domain-containing protein -
HV139_RS17665 3665706..3665885 - 180 WP_115259164.1 hypothetical protein -
HV139_RS17670 3665923..3666516 + 594 WP_137400226.1 fimbria biosynthesis transcriptional regulator FimW -
HV139_RS17675 3666681..3667406 + 726 WP_181629182.1 EAL domain-containing protein -
HV139_RS17680 3667429..3668151 + 723 WP_117342166.1 fimbriae Y protein -
HV139_RS17685 3668742..3669374 + 633 WP_117342165.1 fimbria biosynthesis transcriptional regulator FimZ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3635220..3668151 32931


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(2-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13056.06 Da        Isoelectric Point: 10.6053

>T163813 WP_049100280.1 NZ_CP056644:3664194-3664535 [Citrobacter freundii]
MKPQSAATSRAVKPCLTPVAIWQILLTRLLEQHYGLTLNDTPFRDESVIQEHIDAGITLANAVNFLVEKYELVRIDRRRF
SWQEQSPYLRAVDILRARQATGLLRKNRNNAVR

Download         Length: 342 bp

>T163813 NZ_CP072763:2261204-2261602 [Mycobacterium tuberculosis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11899.58 Da        Isoelectric Point: 6.9463

>AT163813 WP_023326101.1 NZ_CP056644:3663856-3664173 [Citrobacter freundii]
MSNITWGLRRDITPRLGARLVQEGNRLHYLADRASMTGKFSDAECQKLDETFPHFISQMESMLTTGELNPLHVHCVTLYH
TGFTCEADTLGSCGYVYIAIYPTKR

Download         Length: 318 bp

>AT163813 NZ_CP072763:2260976-2261203 [Mycobacterium tuberculosis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References