Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2429327..2430096 Replicon chromosome
Accession NZ_CP056644
Organism Citrobacter freundii strain RHBSTW-00267

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HV139_RS11525 Protein ID WP_137400129.1
Coordinates 2429614..2430096 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HV139_RS11520 Protein ID WP_174360861.1
Coordinates 2429327..2429623 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV139_RS11505 2424827..2426014 + 1188 WP_174360862.1 outer membrane protein transport protein -
HV139_RS11510 2426294..2426923 + 630 WP_117342784.1 winged helix-turn-helix transcriptional regulator -
HV139_RS11515 2427232..2429214 + 1983 WP_181630989.1 MBL fold metallo-hydrolase -
HV139_RS11520 2429327..2429623 + 297 WP_174360861.1 DUF1778 domain-containing protein Antitoxin
HV139_RS11525 2429614..2430096 + 483 WP_137400129.1 GNAT family N-acetyltransferase Toxin
HV139_RS11530 2430259..2431050 - 792 WP_181630937.1 SDR family oxidoreductase -
HV139_RS11535 2431199..2432092 + 894 WP_137363300.1 LysR family transcriptional regulator -
HV139_RS11540 2432127..2432411 - 285 Protein_2262 aldo/keto reductase -
HV139_RS11545 2432862..2433911 + 1050 WP_135912050.1 NAD(P)-dependent alcohol dehydrogenase -
HV139_RS11550 2434184..2434975 + 792 WP_181630938.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(26-148)

Antitoxin

Vibrio phage ICP1, Orf50

(5-97)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17739.36 Da        Isoelectric Point: 7.8963

>T163812 WP_137400129.1 NZ_CP056644:2429614-2430096 [Citrobacter freundii]
MEINVTAPALLTEGHELQPFDCGNEVLNDWLRRRAIKNQYLNASRTFVICLESTQRVVGYYSIATGSVSHADLGRSLRQN
MPDPVPVVLLGRLAVDASTQGHSFGKWLLNDAVLRISNLADQVGIKAIMVHAIDGKARAFYEYFGFVQSPIAANTLFYKI

Download         Length: 483 bp

>T163812 NZ_CP072763:c2237580-2237236 [Mycobacterium tuberculosis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11545.13 Da        Isoelectric Point: 5.8990

>AT163812 WP_174360861.1 NZ_CP056644:2429327-2429623 [Citrobacter freundii]
MEKLMQTSARKPTRDKQINIRATDEERAVIDYAASLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDTRYQSFIEQLEAP
VQNVEGRQRLMDVKPEWK

Download         Length: 297 bp

>AT163812 NZ_CP072763:c2237822-2237574 [Mycobacterium tuberculosis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References