Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3579567..3580093 Replicon chromosome
Accession NZ_CP056622
Organism Citrobacter freundii strain RHBSTW-00310

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HV151_RS17255 Protein ID WP_000323025.1
Coordinates 3579567..3579854 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HV151_RS17260 Protein ID WP_000534858.1
Coordinates 3579854..3580093 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV151_RS17235 3574787..3575293 + 507 WP_048233223.1 hypothetical protein -
HV151_RS17240 3575377..3576180 + 804 WP_016149743.1 MBL fold metallo-hydrolase -
HV151_RS17245 3576253..3578697 - 2445 WP_003021928.1 trimethylamine-N-oxide reductase 2 -
HV151_RS17250 3578718..3579515 - 798 Protein_3374 NapC/NirT family cytochrome c -
HV151_RS17255 3579567..3579854 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HV151_RS17260 3579854..3580093 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HV151_RS17265 3580356..3581279 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
HV151_RS17270 3581479..3582051 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
HV151_RS17275 3582694..3584034 - 1341 WP_058671058.1 ISNCY family transposase -
HV151_RS17280 3584109..3584426 - 318 Protein_3380 NapC/NirT family cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T163793 WP_000323025.1 NZ_CP056622:c3579854-3579567 [Citrobacter freundii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T163793 NZ_CP072763:c755775-755338 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT163793 WP_000534858.1 NZ_CP056622:c3580093-3579854 [Citrobacter freundii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT163793 NZ_CP072763:c756026-755772 [Mycobacterium tuberculosis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References