Detailed information of TA system TA163792

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2373656..2374295
• Replicon: chromosome
• Accession: NZ_CP056622
• Organism: Citrobacter freundii strain RHBSTW-00310

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A8B5QF36
• Locus tag: HV151_RS11300
• Protein ID: WP_003020221.1
• Coordinates: 2373656..2373832 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HV151_RS11305
• Protein ID: WP_123924900.1
• Coordinates: 2373879..2374295 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV151_RS11280	2370434..2370664	-	231	WP_003020233.1	DUF2554 family protein	-
HV151_RS11285	2370854..2370979	-	126	WP_003020230.1	DUF2474 domain-containing protein	-
HV151_RS11290	2370979..2371989	-	1011	WP_003020227.1	cytochrome d ubiquinol oxidase subunit II	-
HV151_RS11295	2371989..2373392	-	1404	WP_003843730.1	cytochrome ubiquinol oxidase subunit I	-
HV151_RS11300	2373656..2373832	+	177	WP_003020221.1	type II toxin-antitoxin system HicA family toxin	Toxin
HV151_RS11305	2373879..2374295	+	417	WP_123924900.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HV151_RS11310	2374388..2375797	+	1410	WP_044702348.1	PLP-dependent aminotransferase family protein	-
HV151_RS11315	2376126..2377271	+	1146	WP_181553732.1	ABC transporter substrate-binding protein	-
HV151_RS11320	2377288..2378304	+	1017	WP_003020210.1	ABC transporter ATP-binding protein	-
HV151_RS11325	2378305..2379249	+	945	WP_003843727.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-65)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6769.80 Da
• Isoelectric Point: 11.2510

>T163792 WP_003020221.1 NZ_CP056622:2373656-2373832 [Citrobacter freundii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIIKQLDLQ

Nucleotide

• Length: 177 bp

>T163792 NZ_CP072763:c755775-755338 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15126.36 Da
• Isoelectric Point: 4.5716

>AT163792 WP_123924900.1 NZ_CP056622:2373879-2374295 [Citrobacter freundii]
MRYPVTLTPAVEGGFVVSFPDIPEALTQGNTRHDALQAAQAALITAFEFYFDDNEAIPLPSAVSAEDDYVEIPLSVASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHTTKIDAVQIAARALGKELALTML

Nucleotide

• Length: 417 bp

>AT163792 NZ_CP072763:c755228-754983 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Structures

Toxin

• AlphaFold DB: A0A8B5QF36