Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 832200..832854 Replicon chromosome
Accession NZ_CP056622
Organism Citrobacter freundii strain RHBSTW-00310

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag HV151_RS04040 Protein ID WP_003026936.1
Coordinates 832447..832854 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag HV151_RS04035 Protein ID WP_003026938.1
Coordinates 832200..832466 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV151_RS04010 827400..828833 - 1434 WP_003846391.1 6-phospho-beta-glucosidase BglA -
HV151_RS04015 828955..829683 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
HV151_RS04020 829736..830047 + 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
HV151_RS04025 830210..830869 + 660 WP_003838267.1 hemolysin III family protein -
HV151_RS04030 830963..831943 - 981 WP_048232745.1 tRNA-modifying protein YgfZ -
HV151_RS04035 832200..832466 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
HV151_RS04040 832447..832854 + 408 WP_003026936.1 protein YgfX Toxin
HV151_RS04045 832899..833420 - 522 WP_003026933.1 flavodoxin FldB -
HV151_RS04050 833534..834430 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
HV151_RS04055 834459..835172 + 714 WP_181553672.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV151_RS04060 835178..836911 + 1734 WP_048232743.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T163782 WP_003026936.1 NZ_CP056622:832447-832854 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T163782 NZ_CP072763:c640644-640231 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT163782 WP_003026938.1 NZ_CP056622:832200-832466 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT163782 NZ_CP072763:c640907-640641 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References