Detailed information of TA system TA163779

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4370156..4370691
• Replicon: chromosome
• Accession: NZ_CP056597
• Organism: Citrobacter freundii strain RHBSTW-00334

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HV164_RS20725
• Protein ID: WP_117343582.1
• Coordinates: 4370404..4370691 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4BKM9
• Locus tag: HV164_RS20720
• Protein ID: WP_006688247.1
• Coordinates: 4370156..4370407 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV164_RS20690	4365169..4366017	+	849	WP_135912711.1	alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ	-
HV164_RS20695	4366014..4366772	+	759	WP_181540128.1	phosphonate C-P lyase system protein PhnK	-
HV164_RS20700	4366880..4367560	+	681	WP_117343579.1	phosphonate C-P lyase system protein PhnL	-
HV164_RS20705	4367557..4368693	+	1137	WP_096758663.1	alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase	-
HV164_RS20710	4368696..4369241	+	546	WP_096758664.1	ribose 1,5-bisphosphokinase	-
HV164_RS20715	4369314..4370072	+	759	WP_181625632.1	phosphonate metabolism protein PhnP	-
HV164_RS20720	4370156..4370407	+	252	WP_006688247.1	plasmid stabilization protein	Antitoxin
HV164_RS20725	4370404..4370691	+	288	WP_117343582.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV164_RS20730	4370688..4371017	-	330	WP_096758667.1	hypothetical protein	-
HV164_RS20735	4371086..4373350	-	2265	WP_117343583.1	hybrid sensor histidine kinase/response regulator	-
HV164_RS20740	4373465..4374988	+	1524	WP_096758669.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11139.00 Da
• Isoelectric Point: 10.2830

>T163779 WP_117343582.1 NZ_CP056597:4370404-4370691 [Citrobacter freundii]
MSYTVKFREDALKEWQKLDKTIQQQLAKELKKCGENPHVPSAKLRGIKDCYKIQLRTSRFRLVYQVIDDTLVIAVVAVGK
RERSEVYNLASERLR

Nucleotide

• Length: 288 bp

>T163779 NZ_CP072763:363476-363778 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9215.53 Da
• Isoelectric Point: 4.2965

>AT163779 WP_006688247.1 NZ_CP056597:4370156-4370407 [Citrobacter freundii]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQQLVKLVHERSQQPLVDVDLD
SYL

Nucleotide

• Length: 252 bp

>AT163779 NZ_CP072763:363826-364047 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7X1BT32