Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 4134893..4135598 Replicon chromosome
Accession NZ_CP056597
Organism Citrobacter freundii strain RHBSTW-00334

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag HV164_RS19600 Protein ID WP_106902678.1
Coordinates 4134893..4135216 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HV164_RS19605 Protein ID WP_174719387.1
Coordinates 4135269..4135598 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV164_RS19580 4130885..4131826 + 942 WP_181540071.1 4-hydroxyproline epimerase -
HV164_RS19585 4131823..4132926 + 1104 WP_181540072.1 FAD-binding oxidoreductase -
HV164_RS19590 4132923..4133177 + 255 WP_181540073.1 (2Fe-2S)-binding protein -
HV164_RS19595 4133164..4134420 + 1257 WP_181625601.1 NAD(P)/FAD-dependent oxidoreductase -
HV164_RS19600 4134893..4135216 - 324 WP_106902678.1 TA system toxin CbtA family protein Toxin
HV164_RS19605 4135269..4135598 - 330 WP_174719387.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV164_RS19610 4135640..4135861 - 222 WP_072414024.1 DUF987 domain-containing protein -
HV164_RS19615 4135877..4136350 - 474 WP_107357770.1 DNA repair protein RadC -
HV164_RS19620 4136421..4137239 - 819 WP_181625602.1 DUF945 domain-containing protein -
HV164_RS19625 4137345..4137683 - 339 WP_181625603.1 hypothetical protein -
HV164_RS19630 4137702..4138247 - 546 WP_181625604.1 hypothetical protein -
HV164_RS19635 4138306..4138995 - 690 WP_181625605.1 WYL domain-containing protein -
HV164_RS19640 4139191..4140081 - 891 WP_181625606.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(2-102)

Antitoxin

Antitoxin CbeA

(8-108)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12247.17 Da        Isoelectric Point: 6.2133

>T163777 WP_106902678.1 NZ_CP056597:c4135216-4134893 [Citrobacter freundii]
INQRAVQLCPSPVTIWQTLLTRLLEQHYGLALNDTPFGDESVIQEHIDAGITLVDAVNFLVEKYELVRIDRRAFGWLEPS
PYLRAVDILRMRRDMGLLRGCNHTAAM

Download         Length: 324 bp

>T163777 NZ_CP072763:71818-72219 [Mycobacterium tuberculosis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12268.00 Da        Isoelectric Point: 5.5062

>AT163777 WP_174719387.1 NZ_CP056597:c4135598-4135269 [Citrobacter freundii]
VNDDTAEPWWGLSRNVIPCFGARLVQEGNRLHYLADRASLTGQFNEADLLHLDQAFPVLLKQMELMLTCGELNPRHQHCV
TLYAKGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 330 bp

>AT163777 NZ_CP072763:71586-71825 [Mycobacterium tuberculosis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References