Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4096366..4096942 Replicon chromosome
Accession NZ_CP056597
Organism Citrobacter freundii strain RHBSTW-00334

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag HV164_RS19425 Protein ID WP_117342369.1
Coordinates 4096655..4096942 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag HV164_RS19420 Protein ID WP_117342368.1
Coordinates 4096366..4096668 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV164_RS19405 4092834..4094984 + 2151 WP_135912629.1 pyruvate/proton symporter BtsT -
HV164_RS19410 4095092..4095286 + 195 WP_003830038.1 YbdD/YjiX family protein -
HV164_RS19415 4095299..4096255 + 957 WP_146717580.1 GTPase -
HV164_RS19420 4096366..4096668 - 303 WP_117342368.1 BrnA antitoxin family protein Antitoxin
HV164_RS19425 4096655..4096942 - 288 WP_117342369.1 BrnT family toxin Toxin
HV164_RS19430 4097176..4097826 + 651 Protein_3802 restriction endonuclease -
HV164_RS19435 4097849..4098505 + 657 WP_181625597.1 restriction endonuclease subunit S -
HV164_RS19440 4098721..4099065 + 345 WP_181540063.1 endoribonuclease SymE -
HV164_RS19445 4099183..4099347 - 165 WP_117342370.1 DUF1127 domain-containing protein -
HV164_RS19450 4099524..4100936 + 1413 WP_181625598.1 PLP-dependent aminotransferase family protein -
HV164_RS19455 4100978..4101901 - 924 WP_181625599.1 Rpn family recombination-promoting nuclease/putative transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(42-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11362.75 Da        Isoelectric Point: 7.5239

>T163776 WP_117342369.1 NZ_CP056597:c4096942-4096655 [Citrobacter freundii]
MPMEFEWDANKAQSNHRKHGVRFEDAVLVFDDPRHLSRQDRYENGEYRWQTIGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHD

Download         Length: 288 bp

>T163776 NZ_CP072762:3848114-3848524 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTCGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11444.95 Da        Isoelectric Point: 8.5366

>AT163776 WP_117342368.1 NZ_CP056597:c4096668-4096366 [Citrobacter freundii]
MSMIKHKRGSASALSAQHEAELKALANKPDDDIDYSDIPVTEDEQWSEANRGTFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT163776 NZ_CP072762:3847839-3848117 [Mycobacterium tuberculosis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References