Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1116656..1117336 Replicon chromosome
Accession NZ_CP056597
Organism Citrobacter freundii strain RHBSTW-00334

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HV164_RS05260 Protein ID WP_181625722.1
Coordinates 1116656..1116976 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HV164_RS05265 Protein ID WP_181625723.1
Coordinates 1117013..1117336 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV164_RS05245 1112529..1114433 + 1905 WP_181540491.1 5-dehydro-2-deoxygluconokinase -
HV164_RS05250 1114448..1115338 + 891 WP_096756056.1 myo-inosose-2 dehydratase -
HV164_RS05255 1115348..1116166 + 819 WP_181506668.1 5-deoxy-glucuronate isomerase -
HV164_RS05260 1116656..1116976 - 321 WP_181625722.1 TA system toxin CbtA family protein Toxin
HV164_RS05265 1117013..1117336 - 324 WP_181625723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV164_RS05270 1117349..1117819 - 471 WP_029989648.1 DNA repair protein RadC -
HV164_RS05275 1117890..1118711 - 822 WP_181625724.1 DUF945 domain-containing protein -
HV164_RS05280 1119154..1119345 - 192 WP_181625725.1 hypothetical protein -
HV164_RS05285 1119404..1120279 - 876 WP_181625726.1 hypothetical protein -
HV164_RS05290 1120323..1120736 - 414 WP_181625727.1 hypothetical protein -
HV164_RS05295 1121323..1121946 + 624 WP_097443996.1 inovirus Gp2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11994.74 Da        Isoelectric Point: 5.0236

>T163763 WP_181625722.1 NZ_CP056597:c1116976-1116656 [Citrobacter freundii]
MHISTVPATVPVSSRLSPVMVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDCKGF
TWQEQTPFLTATDILRARRAIGIMST

Download         Length: 321 bp

>T163763 NZ_CP072762:2951855-2952295 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12136.86 Da        Isoelectric Point: 6.7054

>AT163763 WP_181625723.1 NZ_CP056597:c1117336-1117013 [Citrobacter freundii]
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTGSFSPIHLQKLEQAFPLFIEQLENMLRSGELNPHQQRQVN
IQLTSLTCIADTRSSCGYVYLTIYPAP

Download         Length: 324 bp

>AT163763 NZ_CP072762:2951581-2951868 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References